Protein Info for mRNA_1776 in Rhodosporidium toruloides IFO0880

Name: 10144
Annotation: K01869 LARS, leuS leucyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1120 TIGR00395: leucine--tRNA ligase" amino acids 31 to 1117 (1087 residues), 971.4 bits, see alignment E=2.5e-296 PF00133: tRNA-synt_1" amino acids 68 to 141 (74 residues), 33 bits, see alignment 4.4e-12 amino acids 221 to 800 (580 residues), 81.9 bits, see alignment E=7e-27 PF09334: tRNA-synt_1g" amino acids 79 to 143 (65 residues), 20.3 bits, see alignment 4.1e-08 amino acids 721 to 805 (85 residues), 33.2 bits, see alignment 5.2e-12 PF01406: tRNA-synt_1e" amino acids 714 to 791 (78 residues), 36.1 bits, see alignment 1e-12 PF08264: Anticodon_1" amino acids 840 to 945 (106 residues), 38.8 bits, see alignment E=1.9e-13

Best Hits

KEGG orthology group: K01869, leucyl-tRNA synthetase [EC: 6.1.1.4] (inferred from 56% identity to cne:CNM01290)

Predicted SEED Role

"Leucyl-tRNA synthetase (EC 6.1.1.4)" (EC 6.1.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1120 amino acids)

>mRNA_1776 K01869 LARS, leuS leucyl-tRNA synthetase (Rhodosporidium toruloides IFO0880)
MAPAAPASQAKPASTVAPPAQNTSKRDFLISLEQQAQKRWAQDRLFEQDSPYATGEAEIP
SEEFAKHAAELREKYPKVLATMPYPYMNGSLHLGHGFTISKIEFLTGFERMRGKRALWPF
GFHATGMPIKAAADKLIREMEMFGEEFEKYGQPEDETVTATEEPGNATALATTSTTSSND
PARAKKGKLAAKNTGLQYQFQIMESIGVPRSEIKKFADPYHWLKYFPPIAQDDLNALGSR
IDWRRSFITTPANPYYDAFVRWQMNKLHGLGYIKFGKRYTIFSPKDGQPCMDHDRQSGEG
VGPQEYVGMKLEVTQWGERAERVKQLAGGKKVFMVAATLRSETMHGVTNLFVAPSVKYGL
YPSSTTKGSKEDVLYLVTPRAARNMAYQGLLRTEDKVECVGELEGSELLGTKVHPALSEH
KEVYVVPMDTIKDNKGTAVVICMPSDSPDDWITTLDLRKKPEYYNIDPEWVALEPVPVLT
TPTYGDKTAVAIVEKMKINSPKDTKQLAEAKELAYKEGFYGGTMIVGKYKGEKVEDVKNK
IRDDLIAQDLAFIYSEPENLVMSRSGDECVVALCDQWYLDYGEAGWLKKAELLLSRMNTY
QPETRNGFEKTLGWLRQWACARSYGLGSKLPWDPQFLVESLSDSTIYMAYYTIAHLLHGP
PIDGSKVGPLGITAEQMTDEMWEYIFANGPFPSHSPVPIEKLNRLKAEFSYFYPMDIRSS
GKDLIPNHLTFCIYVHAALFGEEHWPRSMRANGHLMLNGEKMSKSTGNSLTLKDSLVKFG
ADATRVTLADAGDSIEDANFEESTANAAILRLHTLIEWCQEVVKDQGQLRRGASDELIWD
RIFENEINEAIELTYKAYDQALYKDALKNGFYQLLSARDLYQLATASEGGMHVDIALRFI
RIQALLLTPIAPHVAEHLWSTVLGEQSSVQKAQFPTISKPVDRATTDAAVYVRSKVKEIR
DAELSFAKKKAKGKATGAFDPSKPKACKVWVAKGFPEWQEAAVEIVKSAWTGSAVNDKKV
KEDLVARGLIKDKRYMPFIAQLKKGIAQFGFQEAIDRHITFDEVATLNAAMPYIRRSLGM
DDIEVLHTDSDKAKEGEPGFVASIVEAAQPGNPGLVLYNI