Protein Info for mRNA_2131 in Rhodosporidium toruloides IFO0880

Name: 10499
Annotation: K09580 PDIA1, P4HB protein disulfide-isomerase A1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details TIGR01130: protein disulfide isomerase" amino acids 19 to 439 (421 residues), 427.4 bits, see alignment E=1.8e-131 PF00085: Thioredoxin" amino acids 21 to 120 (100 residues), 94.4 bits, see alignment E=1.2e-30 amino acids 354 to 438 (85 residues), 78.8 bits, see alignment E=8.6e-26 TIGR01126: protein disulfide-isomerase domain" amino acids 26 to 121 (96 residues), 110 bits, see alignment E=1e-35 PF01216: Calsequestrin" amino acids 58 to 285 (228 residues), 42.1 bits, see alignment E=1.9e-14 PF13848: Thioredoxin_6" amino acids 151 to 331 (181 residues), 122.8 bits, see alignment E=4.9e-39

Best Hits

Swiss-Prot: 52% identical to PDI_HUMIN: Protein disulfide-isomerase from Humicola insolens

KEGG orthology group: K09580, protein disulfide-isomerase A1 [EC: 5.3.4.1] (inferred from 51% identity to cci:CC1G_00344)

Predicted SEED Role

"Glycine betaine / L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>mRNA_2131 K09580 PDIA1, P4HB protein disulfide-isomerase A1 (Rhodosporidium toruloides IFO0880)
MRTSAVLSLVGLATAAFASDVVDLTGSTFPDFAAQDLTLIEFFAPWCGHCKALAPHYEEA
ATILKKDKIPIAKVDCTVESDLCSSQGVNGYPTLKVFRKGVPAEYGGTRKTDGIVSYMKK
QALPAVSDVTAENHDEFKTADKVVLVAYVDESDSKTQKTFREFADQYRDDYLFGLSTDAA
AIAAANVKPPAVVMYKTFDEGRNELEGKISSESLLTFAKEHSVPLLDEISPDNFATYAEA
GIPLAYIFVPANDPKREEIVKAIEPVAREHKGKINFVWIDSNKFADHAKSLNLQEPTWPA
FAIQNIQAMTKFPLDQSKTVDFATVSSFVKDFANGKIQPSIKSQKAPAVQDEPVYVLVAD
EFDKVVAEDKDLLVEFYAPWCGHCKKLKPTWDTLGERYSNAKSKITVAKFDATENDIPST
AGFRVAGFPTIKFKAAGSSEWISKLLIERMRREQ