Protein Info for mRNA_3278 in Rhodosporidium toruloides IFO0880

Name: 11646
Annotation: K14152 HIS4 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 878 PF01502: PRA-CH" amino acids 215 to 293 (79 residues), 83.7 bits, see alignment E=1.3e-27 TIGR03188: phosphoribosyl-ATP diphosphatase" amino acids 299 to 378 (80 residues), 65.9 bits, see alignment E=3e-22 PF01503: PRA-PH" amino acids 300 to 381 (82 residues), 53.6 bits, see alignment E=5.2e-18 PF03819: MazG" amino acids 325 to 380 (56 residues), 21.5 bits, see alignment 4.5e-08 PF00815: Histidinol_dh" amino acids 452 to 870 (419 residues), 515 bits, see alignment E=3.2e-158 TIGR00069: histidinol dehydrogenase" amino acids 465 to 869 (405 residues), 477.8 bits, see alignment E=3.2e-147

Best Hits

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (878 amino acids)

>mRNA_3278 K14152 HIS4 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase (Rhodosporidium toruloides IFO0880)
MSFSQVPFLPLIEQEPSQLDSKLLPALARIVPLLVPASLAASTLPHLPSNAEHYILDDAQ
LNLEDAIAYLDKGARRVVSKNTAFLTAVPAERLIFHLEKPDAAFLSNPDLLASISGVLLE
TETFVEEDLKPVRVAIKKKASGRPLDLFVLSAVRTAEKVLAQPAAFKLMSKTVGGTSVIP
SLATLFTSALRSDRQDGLFVTVPISLTSVTTPLGLVYSSHESVAHSILSGNAVYYSRSRN
GLWRKGETSGAMQLVERIRIDCDFDALEFGVIESGPNGEKEGFCHVPEQTSCFGGIAGLA
ELESTLKKRMAEAPAGSYTKRLFDEPKLLRAKIMEEAGEVCDAETKEDLAGEVADLLYFT
LTRAVSMGVSLKDVQQVLEKRSLKVTRRKGDAKLQWHMQASLGSAGAAQASAGREKRAAR
SLGAGSTGLAGYRCPVYSSSNIDAEKRAQLLERPVKSSKDILALVSPILQSVREGGDDGL
RSCVVKFDRCVPAEDAGFPLTLQAPFSDELARIDPKVKEAIDVAYKNIKAFHGAQMERES
EPIRVETMPGVVCQRFARPIGSVGLYIPGGTAVLPSTALMLGVPAQVAGCKNITLATPPR
PDGSISPEIIYIAQLVGAKTVVKAGGAHAIAAMAYGTKSVPKADKLYGPGNQFVTAAKMM
VAMDSGAKCAIDVPAGPSEVLIIADKTADPVLVASDLLGQQEHGLDSQSVLVTIDCDDSY
VEAVNAAVEQQAQALPRAEILRKSLSQSFILQTRSVEEAFEFSNDYAPEHLLLYLKDAAK
TVELVENAGSVFVGPWSPVACGDYASGTNHTLPTVGYAKQYSGVSTSSFLKHFTSQELSS
NGLKNLGPYVEILADVEQLGAHKASVSLRLDKIKREDL