Protein Info for mRNA_3486 in Rhodosporidium toruloides IFO0880

Name: 11854
Annotation: K04563 CDC28, CDC2 cyclin-dependent kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 PF00069: Pkinase" amino acids 6 to 289 (284 residues), 245.7 bits, see alignment E=8.6e-77 PF07714: Pkinase_Tyr" amino acids 9 to 278 (270 residues), 111.1 bits, see alignment E=9.2e-36

Best Hits

Swiss-Prot: 68% identical to CDK1_SCHPO: Cyclin-dependent kinase 1 (cdc2) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)

KEGG orthology group: K04563, cyclin-dependent kinase [EC: 2.7.11.22] (inferred from 73% identity to cne:CNC01750)

Predicted SEED Role

"Transcription initiation factor IIH cyclin-dependent kinase 7" in subsystem RNA polymerase II initiation factors

Isozymes

Compare fitness of predicted isozymes for: 2.7.11.22

Use Curated BLAST to search for 2.7.11.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (296 amino acids)

>mRNA_3486 K04563 CDC28, CDC2 cyclin-dependent kinase (Rhodosporidium toruloides IFO0880)
MSLDKYERLEKVGEGTYGVVYRSRNKETGEIVALKKIRLEADDEGVPSTAIREISLLKEM
KDPNVVRLLDINHHDTKLYLVFEFLDLDLKRYMDKVGDGDGMGPEIVKKFTYQLIRGVYY
LHAHRVLHRDLKPQNLLINKEGNLKLADFGLARAFGIPLRTYTHEIVTLWYRAPEVLLGS
RHYSTGVDMWSVGCIFAEMIMRQPLFPGDSEIDEIFRIFRLLGTPDEDVWPGVTNLPDYK
TTFPHWHAKDIMDHVPGCMEESAELIIGMLAYDPSKRMSAKAALKSAYFDHGAYGA