Protein Info for mRNA_3542 in Rhodosporidium toruloides IFO0880
Name: 11910
Annotation: K01597 MVD, mvaD diphosphomevalonate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 65% identical to MVD_GANLU: Diphosphomevalonate decarboxylase (mvd) from Ganoderma lucidum
KEGG orthology group: K01597, diphosphomevalonate decarboxylase [EC: 4.1.1.33] (inferred from 64% identity to cci:CC1G_02299)Predicted SEED Role
"Diphosphomevalonate decarboxylase (EC 4.1.1.33)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis (EC 4.1.1.33)
MetaCyc Pathways
- superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (10/10 steps found)
- mevalonate pathway I (eukaryotes and bacteria) (7/7 steps found)
- isoprene biosynthesis II (engineered) (7/8 steps found)
- superpathway of ergosterol biosynthesis I (16/26 steps found)
- superpathway of cholesterol biosynthesis (14/38 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (26/57 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Terpenoid biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.33
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (412 amino acids)
>mRNA_3542 K01597 MVD, mvaD diphosphomevalonate decarboxylase (Rhodosporidium toruloides IFO0880) MSPSPVYEATCTAPVNIAVVKYWGKRDTSLILPTNSSLSVTLSQDHLRSLTSARCITSGG ADARDRLWLNGEEEEIKQGGRTERCLSEMRKMRKEFEASNSSLPRIADFPIHIASENNFP TAAGLASSASGLSALIATLSTLYALTPENGVSVSDLSRIARQGSGSACRSMFGGYVAWEM GLKDDGSDSVAVEVAPVEHWPDLHALILVVSDKKKGTPSTAGMQRTVATSALLQHRIKEV VPARMQRITTAIQKRDFDAFAEETMADSNQFHAVCLDTFPPIFYMNDVSRAVIQLVTELN RASVEKGEGVKAAYTYDAGPNAVLYVQEKDVKQVLELVLRYFPQTTESFPDPFNLGAKPA SDVPQGFNKAVIPEHEVGAVARIIHTKVGDGPRVLAKEQSLLNAEGMPKSLK