Protein Info for mRNA_3584 in Rhodosporidium toruloides IFO0880

Name: 11952
Annotation: K00122 FDH formate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00389: 2-Hacid_dh
  • amino acids 32 to 340 (309 residues), 76.9 bits, E=1.8e-25
• PF02826: 2-Hacid_dh_C
  • amino acids 127 to 299 (173 residues), 159.8 bits, E=7.1e-51

Best Hits

Swiss-Prot: 67% identical to FDH_EMENI: Formate dehydrogenase (aciA) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)

KEGG orthology group: K00122, formate dehydrogenase [EC: 1.2.1.2] (inferred from 69% identity to zma:100501669)

MetaCyc: 62% identical to formate dehydrogenase ([Candida] boidinii)
1.2.1.2-RXN [EC: 1.17.1.9]

Predicted SEED Role

"NAD-dependent formate dehydrogenase (EC 1.2.1.2)" in subsystem Formate hydrogenase (EC 1.2.1.2)

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• purine nucleobases degradation II (anaerobic) (14/24 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.1.9 or 1.2.1.2

Protein Sequence (362 amino acids)

>mRNA_3584 K00122 FDH formate dehydrogenase (Rhodosporidium toruloides IFO0880)
MTKVLVVLYSGGKHAEEQPKLLGTVENALGLRPYCEKHGLDLVVTDDKEGDNSTFAKEIV
DADVLITTPFHPGYLTAEMVKKAKNLKLAITAGVGSDHIDLNAANEHKITVAEVTGSNVV
SVAEHVVMTILVLVRNFVPAHEQIVSGGWEVAAVAKAAYDLEGKVVGTLGAGRIGFRVLQ
RLKPFDCKELLYYDYTELPADAAKEVGARRVEDLKEFLSACDVVTLNCPLHEGTRGIINK
ETLGYMKKGAWLVNTARGALCVAEDVAEAVNSGHLAGYGGDVWPRQPAPADHPWRKMQNP
FSKGGSAMVAHYSGTTLDAQKRYADGAIQILDRWRNGQAQEPANLIVENGAYATKAYGQR
TK