Protein Info for mRNA_4202 in Rhodosporidium toruloides IFO0880
Name: 12570
Annotation: K00249 ACADM, acd acyl-CoA dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 60% identical to ACADM_HUMAN: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) from Homo sapiens
KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 67% identity to mgl:MGL_3154)MetaCyc: 60% identical to mitochondrial medium-chain acyl-CoA dehydrogenase monomer (Homo sapiens)
RXN-11734 [EC: 1.3.8.7]; 1.3.8.7 [EC: 1.3.8.7]
Predicted SEED Role
"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)
MetaCyc Pathways
- oleate β-oxidation (26/35 steps found)
- fatty acid salvage (5/6 steps found)
- pyruvate fermentation to butanol II (engineered) (4/6 steps found)
- pyruvate fermentation to hexanol (engineered) (7/11 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
KEGG Metabolic Maps
- Butanoate metabolism
- Fatty acid metabolism
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.3.99.2, 1.3.99.3
Use Curated BLAST to search for 1.3.8.7 or 1.3.99.2 or 1.3.99.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (416 amino acids)
>mRNA_4202 K00249 ACADM, acd acyl-CoA dehydrogenase (Rhodosporidium toruloides IFO0880) MLSRLALRTSRTARLSTRSTRAYASEASEYTGGPTFELSEEQVGIRDLARSFTANEIIPV AAEYDRTMKYPWEVIKKAHAEGLLNVHVPEEYGGAGLSVMSSSIVSEELAYGCTGIQTAI EANGLASAPLIVAGSDAQKRSYLGRLTEEPLMCAYGVSEPGAGSDVASIKTKATREGDKF VLNGQKCWITNGGVANWYFVLAKTDPTAKPHKALSGFIVDASTPGITVENKLINMGQRCS DTRIINFENVVVGKENLLGREGDGFKIAMGAFDITRPLVASGAVGLAQRALAEAAKYAHD RKTFGVPIIQHQAIGTLLAEMAIGVETARNAVWRAACAKDNNDPRTTYLASVAKAYASRV AVTNADKCVQIHGGAGYNTEYPAEKLFRDSKIFELYEGTTQIQNLIVSRVVANDYA