Protein Info for mRNA_4274 in Rhodosporidium toruloides IFO0880

Name: 12642
Annotation: K01720 prpD 2-methylcitrate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 533 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details TIGR02330: 2-methylcitrate dehydratase" amino acids 76 to 530 (455 residues), 656.7 bits, see alignment E=1e-201 PF03972: MmgE_PrpD" amino acids 79 to 512 (434 residues), 480.7 bits, see alignment E=1.9e-148

Best Hits

Predicted SEED Role

"2-methylcitrate dehydratase (EC 4.2.1.79)" in subsystem Methylcitrate cycle or Propionate-CoA to Succinate Module (EC 4.2.1.79)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.79

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (533 amino acids)

>mRNA_4274 K01720 prpD 2-methylcitrate dehydratase (Rhodosporidium toruloides IFO0880)
MLSLRTSSRSLAQSIAAPASRRAVSSLVANPAVRPSLLSSARSSASHRTQTALTAAMGAT
RLSHHSGESTVRPPADKVMQDIADYVHNYEIKSDLAYSTARLCLIDTIGCGLEGLRVSEE
CRALMEPIVPGTTVPNGTKVPGTPFQMDPVRGAFAIGTQIRWLDFNDCFLAAEWGHPSDN
LGAILAVADYLSRSGEPLKMRDVLTAMIKAHEIQGCMALENSFNRVGLDHVILVKLASAA
VVSQMLGLTRDQTVDVISQVFVDGQSLRTFRHAPNTGSRKSWSAGDACMRAVHLALQVKR
GQMGIPTVLTAKTWGFYDVLFKGQEFKFQRPYASAELRADDAQTAAEGAHILHKQLKEMG
KSSDDIKSVKIRTQEAAIRIIDKSGPLDNFADRDHCIQYMVAVPLIYGRLTTEDYSDKVA
ADPRIDALRDKMYCVEDKQFTSDYHSPDKRYISNGLTVTLNDGTVLPEVHIDFPVGHKNR
REEGTPLLNAKFERHIKPHFDSAHVDKILEVVGDQSALENLSVKEFSDLFHKP