Protein Info for mRNA_4499 in Rhodosporidium toruloides IFO0880

Name: 12867
Annotation: K01968 E6.4.1.4A 3-methylcrotonyl-CoA carboxylase alpha subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 828 PF00289: Biotin_carb_N" amino acids 90 to 198 (109 residues), 154.6 bits, see alignment E=4.5e-49 PF02786: CPSase_L_D2" amino acids 207 to 421 (215 residues), 227.8 bits, see alignment E=3.9e-71 PF02222: ATP-grasp" amino acids 244 to 388 (145 residues), 26.5 bits, see alignment E=1.5e-09 PF07478: Dala_Dala_lig_C" amino acids 245 to 389 (145 residues), 32.8 bits, see alignment E=1.9e-11 PF02785: Biotin_carb_C" amino acids 435 to 542 (108 residues), 115.3 bits, see alignment E=5.1e-37 PF00364: Biotin_lipoyl" amino acids 754 to 818 (65 residues), 64.4 bits, see alignment 2.5e-21

Best Hits

Predicted SEED Role

"Methylcrotonyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism or Serine-glyoxylate cycle (EC 6.4.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.4

Use Curated BLAST to search for 6.4.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (828 amino acids)

>mRNA_4499 K01968 E6.4.1.4A 3-methylcrotonyl-CoA carboxylase alpha subunit (Rhodosporidium toruloides IFO0880)
MRRIAVQHSTRASSLSRRATPLAGSPRSIVAGISSSPHTASQRSNAALSSSPALLVPRRH
ASTTSAPSSAFMGGYNLPQDQNGANKKPLFDKILIANRGEIACRVIRTARRLGIKTVAVY
SDPDKDSMHVKMADEAYWIGPAPSAESYLRMDRYIDICRRSGAQAIHPGYGFLSENAEFA
KLLEKEGIVFIGPPKEAIRAMGSKAESKDIMLAAGVPCIPGWHPSSSSIPAGEDPQSLPF
LLARADEIGYPVLIKAVSGGGGKGMKIVGRREEFAEQLESAKREARKSFGDDEVLLERYI
TRPRHVEVQVFSDSHGNHLSLFERDCSVQRRHQKIIEEAPAPGLPNELRERLYEEARKAA
RAVGYRGAGTVEFILNADNIDEFFFCEMNVRLQVEHPVTEAVTGVDLVEWQLEVAAGNPI
PLSQDQITCTGHAFECRVYAENPRNGFLPDTGRLLHHRPPASSDSVRMETGFEAGDEISV
HYDPLLSKLIVRGEDRDAALRALRKALNEYQVVGPSTNLEFLGRLASNEAFIRAEVETGF
IQKHYDELFPPLPSATPATLATSALYLAQRDFLQYASQGQQSAWTDSKLAGFRLAVSNDG
QGRYKRGYELGSVAAKDGAEVEEVNAQVKVGPAAAGAKDGFDVEVAAAPAGSASETETVL
FSNVAPTFDAFTPTAPNAATINAPLSSHLSRVTIVSPPPSNLTSAALPSSGTLHVFNTAE
SFAGKVEVKQPKWMSKVGMANGAAGKASAGGGAKAPMPSKIVQVFVKEGDAVEEGQPLVA
VEAMKTEHVLRASKAGKVGKVLVKEGDLVPEGKVLVTLAEEEGAEKAE