Protein Info for mRNA_4609 in Rhodosporidium toruloides IFO0880

Name: 12977
Annotation: K00008 SORD, gutB L-iditol 2-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08240: ADH_N
  • amino acids 59 to 169 (111 residues), 90 bits, E=9.1e-30
• PF00107: ADH_zinc_N
  • amino acids 210 to 343 (134 residues), 60.7 bits, E=1.6e-20

Best Hits

Swiss-Prot: 58% identical to LAD_NEUCR: L-arabinitol 4-dehydrogenase (ard-1) from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

KEGG orthology group: K00008, L-iditol 2-dehydrogenase [EC: 1.1.1.14] (inferred from 66% identity to cci:CC1G_00854)

MetaCyc: 54% identical to D-galactitol dehydrogenase / L-arabinitol 4-dehydrogenase (Trichoderma reesei)
L-arabinitol 4-dehydrogenase. [EC: 1.1.1.12]; 1.1.1.- [EC: 1.1.1.12]

Predicted SEED Role

No annotation

MetaCyc Pathways

• D-sorbitol degradation I (2/3 steps found)
• D-galactose degradation IV (1/3 steps found)
• L-arabinose degradation II (1/3 steps found)
• superpathway of pentose and pentitol degradation (6/42 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism
• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.12 or 1.1.1.14

Protein Sequence (384 amino acids)

>mRNA_4609 K00008 SORD, gutB L-iditol 2-dehydrogenase (Rhodosporidium toruloides IFO0880)
MPDYPTAYDPARVLQHADFKILEDGTIPQRDTSKNVAAAYAPQAKLHLIEKPVPKPREGE
VVVHVRATGICGSDCHFWKHGRIGDSMVVSNTCGAGHESAGEVYEVGPGVEGLKKGDRVA
LEAGLPCGECEICRIGRYNACPDVVFFSTPPYHGMLTRYHAHPASWVHRLPDSISFEEGA
LLEPLVVALAGIERAGLRLGDPLLICGAGPIGLISLLAARAAGATPIVITDIAQSRLDVA
KQLVPGVKTVLVERGIEPKDVAAKIKKEAGLSLGLSVALECSGVESSVQTAVYASKFGGT
VFVIGAGKDFQSLPFMHMSVNEIDLKFQYRYANQYPKAIRLVEAGLINLKPLVTHRFTLE
TAIEAFETAVDVTRGGASLSLHSP