Protein Info for mRNA_5719 in Rhodosporidium toruloides IFO0880

Name: 14087
Annotation: K00290 LYS1 saccharopine dehydrogenase (NAD+, L-lysine forming)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 398 transmembrane" amino acids 136 to 154 (19 residues), see Phobius details PF05222: AlaDh_PNT_N" amino acids 6 to 144 (139 residues), 85.4 bits, see alignment E=2.4e-28

Best Hits

Swiss-Prot: 61% identical to LYS1_NEUCR: Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (lys-4) from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

KEGG orthology group: K00290, saccharopine dehydrogenase (NAD+, L-lysine forming) [EC: 1.5.1.7] (inferred from 65% identity to uma:UM04268.1)

Predicted SEED Role

"Saccharopine dehydrogenase [NAD+, L-lysine-forming] (EC 1.5.1.7)" in subsystem Lysine degradation (EC 1.5.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (398 amino acids)

>mRNA_5719 K00290 LYS1 saccharopine dehydrogenase (NAD+, L-lysine forming) (Rhodosporidium toruloides IFO0880)
MALNLWLRCETKEFEHRSALTPTTAKQLIDSGRFSVTVERDPQRIFDDEEFERVGCKLVE
HNSWPSAPLSSPIIGLKELPPNDTSPLPHTHIMFAHCYKQQGGWVDVISRWEAGQPTGML
YDLEFLQDEKGRRVAAFGYHAGFAGAAVGLLALAKQVSSEGEKERLGEIKPYPNEGELIK
FVKGQMAVIEKQLGRKPRALVIGALGRCGRGAVDFFKAAGFEDDNIAKWDMAETAKGGPF
QEILDADVFVNCIYLTSKIPSFISPESIAAAGDKRQLRVVVDVSCDTTNPNNPIPIYSIN
TTFDKPTVDVDGITAGPPMTVVSIDHLPTLLPREASEAFSTDLLPSLLTLPEAIAERQPR
QGKPVPAADVGDGPERVWKQSEELFWRVLAQAQAEKKQ