Protein Info for mRNA_5891 in Rhodosporidium toruloides IFO0880

Name: 14259
Annotation: K11788 ADE5 phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 796 PF02844: GARS_N" amino acids 14 to 114 (101 residues), 114.4 bits, see alignment E=8.6e-37 TIGR00877: phosphoribosylamine--glycine ligase" amino acids 14 to 435 (422 residues), 542.3 bits, see alignment E=7.7e-167 PF01071: GARS_A" amino acids 115 to 307 (193 residues), 275.8 bits, see alignment E=5.2e-86 PF02843: GARS_C" amino acids 344 to 432 (89 residues), 103.5 bits, see alignment E=1.5e-33 TIGR00878: phosphoribosylformylglycinamidine cyclo-ligase" amino acids 446 to 776 (331 residues), 433.3 bits, see alignment E=6.2e-134 PF00586: AIRS" amino acids 501 to 604 (104 residues), 55.5 bits, see alignment E=1.9e-18 PF02769: AIRS_C" amino acids 617 to 781 (165 residues), 130 bits, see alignment E=2.3e-41

Best Hits

Swiss-Prot: 63% identical to PUR2_YARLI: Bifunctional purine biosynthetic protein ADE1 (ADE1) from Yarrowia lipolytica (strain CLIB 122 / E 150)

KEGG orthology group: K11788, phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1 6.3.4.13] (inferred from 64% identity to scm:SCHCODRAFT_49871)

MetaCyc: 55% identical to ADEnine requiring (Saccharomyces cerevisiae)
Phosphoribosylamine--glycine ligase. [EC: 6.3.4.13]; Phosphoribosylformylglycinamidine cyclo-ligase. [EC: 6.3.4.13, 6.3.3.1]

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1 or 6.3.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (796 amino acids)

>mRNA_5891 K11788 ADE5 phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase (Rhodosporidium toruloides IFO0880)
MAQADPLFEPEKLRILLVGGGGREHALAWKLSQSARVEKIFVAPGNGGTTTGEKTVSVPV
AAEDFKGLLDFAVKNEVNFVVVGPEQPLVDGIEGIFRKAGIPVFGPNVRAAAMEGSKAFS
KDFMARHSIPTAEYRNFTSHSAAVEYVKSVSHNVVLKASGLAAGKGVIIPSSKEEAIAGL
NDIMVSKEFGAAGEEVVVEEFMTGQELSILAFSDGYTALALPAAQDHKRIGEGDTGLNTG
GMGTYSPAPVATKEVEAEIMRTIVQPTIDGMRKDGIPFVGMLFTGIMLTPTGPKVLEYNV
RFGDPETQSLLALLSNDTDLAEIMVACVERRLDCVKFEMKKEAAVSVVLAAKGYPGSYPK
GDEITIDALPPNVYVFHAGTKATPEGKVVTNGGRVLAVTATAPTLKEAQALAYKGVDCVH
FEGKTFRRDIAYKAFLQEEQQKPQGMTYASAGVSIDAGNALVERIKPMVKATKRAGTDSV
IGGFGGLFDLKAAGFKDPILVGGTDGVGTKLKIAQTYGKHDTIGIDLVAMSVNDLIVQGA
EPLFFLDYYACGHLDVDTAADVVKGVAEGCLQSGCALVGGETAEMPSLYEGEDYDVAGFA
VGAVERELVLPQPTIAPGDVLLGIASSGVHSNGFSLVRKIVSAHGYDYHSKLPYDTSRTL
GDELLTPTTLYVKQLLPAIRKGLIKGLSHITGGGFTENIPRVLPKGVGCYVDAGSFTFLP
VFRWLMGLGGVAPEEMARVFNCGIGMVVVVAQDKADEVEQSLRANGQAEVFRIGETVAGE
GCEMRNLDKWVEASRQ