Protein Info for mRNA_6062 in Rhodosporidium toruloides IFO0880

Name: 14430
Annotation: K11121 SIR2 NAD-dependent histone deacetylase SIR2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 PF02146: SIR2" amino acids 37 to 61 (25 residues), 24.8 bits, see alignment (E = 9.9e-10) amino acids 123 to 154 (32 residues), 22.8 bits, see alignment (E = 3.9e-09) amino acids 188 to 296 (109 residues), 31.5 bits, see alignment E=8.2e-12

Best Hits

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (509 amino acids)

>mRNA_6062 K11121 SIR2 NAD-dependent histone deacetylase SIR2 (Rhodosporidium toruloides IFO0880)
MQTVRFVPGNESAAATKALDAVALAVAKGKRTVLLVGAGISTNAGIPDFRSSGTGLYSSG
SSSSPSPLPPTTLKGPDLFSASVYSSPDTTAEHLRFIAHFKQSLDDIEQRCSSASPSGTA
STRVATATHDFMRLLKKRGKLQRVYTQNIDGLEGVGTGLVPVALEGITATASLPEGKGKG
KAKIEGDYVQLHGSVHAVRCTSCAFVRRWTEEDVEAFEAGHVGACPECEEKAALRSACGQ
RTLTSLSRAYLRPSIVLYSESPPSSSSLTIGTLSLSDLSSQPGPDVMLVLGTSLRIPGFK
KLVKEFSRSVGSRGGVRVLVNREEIGGRSEWKGVFDYEVIADTDSFVTRLIEGWKRLRPQ
DWTGRQATLGEVFGPNASGKKGVSTGANGQETPTPRSSLTQLAPYPPSRASYQPISLDRP
PHSTQTLPPQQSSSNAFSDPDKAPSYLLLLGASADEEFVEDAVQWIAPSHAFKANDSYFP
ARLLVLRLGPTTRYASCVGEQSGGSSSGR