Protein Info for mRNA_6291 in Rhodosporidium toruloides IFO0880

Name: 14659
Annotation: K12182 HGS, HRS, VPS27 hepatocyte growth factor-regulated tyrosine kinase substrate

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 643 PF00790: VHS" amino acids 9 to 155 (147 residues), 86.8 bits, see alignment E=1.9e-28 PF01363: FYVE" amino acids 184 to 242 (59 residues), 60.2 bits, see alignment 2.6e-20 PF02809: UIM" amino acids 285 to 300 (16 residues), 14.2 bits, see alignment (E = 5e-06) amino acids 340 to 354 (15 residues), 11.8 bits, see alignment (E = 3.1e-05)

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (643 amino acids)

>mRNA_6291 K12182 HGS, HRS, VPS27 hepatocyte growth factor-regulated tyrosine kinase substrate (Rhodosporidium toruloides IFO0880)
MSFLWGPTQQQQEWDTLIDKTTSDLLPAQTPLDLVAALQLADLVRSASVIPAYASRSLLR
RIQHDNPNVQLLALELCDVCVKNGGTAFLVQFAKTAFEGGVATDLELLARGVKSGGSVHR
DVKEKVLARLQDWATAFKGKDQLRDSELVRAYDKLVKEGVQFPPRDPTATTAMVDSLSAP
DWTDSPYCTRCRTEFSTFNRKHHCRNCGQVFDQQCSSSVAPLPHYGILEPVRVCDGCAKK
IREGKGGSVQRSASYSAGQGEGKRPAQVERSKTVGAKGGLSRKEQEDEELRKAIEASLKE
VEPDQLPRADPGPPAKSGYNPSYASQISDSKGSSAKKDEEDDPDLAAAIAASLRDLQPPA
TAPTFARSESEMTVPTSTAYSSLFLSSTAYDSPSASRPKPMSLPSYDLSATESALLSDFT
SLFASPSYPPYLGPKERRMYEEAHAAQGRLDRAMEDARRRREILSEMESKLGEAARLYGA
GLTERASYRPPLTNRLSSYSATSQAYSQPQHHQPYHAPPAAAQSLDARYQYAPPPALTGQ
PLPAYAVPVAPVPPLAQHAEIASPPPAQAYSQPPHHAHARAQPQRQPSQAVPAGYYKSSS
FPSVPTGAQGALFPTVPKGELPVEEEREQEEEERGRTGELIEL