Protein Info for mRNA_6294 in Rhodosporidium toruloides IFO0880

Name: 14662
Annotation: K00928 lysC aspartate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00696: AA_kinase
  • amino acids 17 to 378 (362 residues), 118.5 bits, E=5.9e-38
• TIGR00657: aspartate kinase
  • amino acids 141 to 577 (437 residues), 294.9 bits, E=6e-92
• PF13840: ACT_7
  • amino acids 510 to 574 (65 residues), 35 bits, E=1.6e-12
• PF01842: ACT
  • amino acids 523 to 570 (48 residues), 27.8 bits, 2.6e-10

Predicted SEED Role

"Aspartokinase (EC 2.7.2.4) / Homoserine dehydrogenase (EC 1.1.1.3)" in subsystem Lysine Biosynthesis DAP Pathway or Threonine and Homoserine Biosynthesis or Methionine Biosynthesis (EC 1.1.1.3, EC 2.7.2.4)

MetaCyc Pathways

• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of L-threonine biosynthesis (6/6 steps found)
• L-homoserine biosynthesis (3/3 steps found)
• superpathway of S-adenosyl-L-methionine biosynthesis (7/9 steps found)
• superpathway of L-methionine biosynthesis (transsulfuration) (7/9 steps found)
• superpathway of L-homoserine and L-methionine biosynthesis (6/8 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (10/15 steps found)
• L-methionine biosynthesis IV (2/4 steps found)
• dipicolinate biosynthesis (2/4 steps found)
• spermidine biosynthesis II (2/4 steps found)
• ectoine biosynthesis (2/5 steps found)
• 3-dehydroquinate biosynthesis II (archaea) (3/7 steps found)
• L-lysine biosynthesis III (3/7 steps found)
• L-lysine biosynthesis VI (3/7 steps found)
• norspermidine biosynthesis (2/6 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (10/18 steps found)
• aspartate superpathway (15/25 steps found)
• cremeomycin biosynthesis (2/7 steps found)
• L-lysine biosynthesis I (3/9 steps found)
• L-lysine biosynthesis II (3/9 steps found)
• grixazone biosynthesis (2/8 steps found)
• superpathway of polyamine biosynthesis III (2/8 steps found)
• platensimycin biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of plant hormones
• Glycine, serine and threonine metabolism
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.3, 2.7.2.4

Use Curated BLAST to search for 1.1.1.3 or 2.7.2.4

Protein Sequence (586 amino acids)

>mRNA_6294 K00928 lysC aspartate kinase (Rhodosporidium toruloides IFO0880)
MSAPAKLRGNPPAPAPIVVQKYGGTSVGKQLHMITGNIVPQYLNDGYRVVVVCSARSGNT
KATGTTNLLLRAALEAIRPKGPDLSSSVPSLRNSPSQSPAPGTPVTPRQSYLSGSLSNLR
MTASGVGLDKMNGDDDRQLFDDTVDQIKRDHLEAAQKTIVNSKEVLQEVEEELEYDCERL
RGFLRAAQIIDEISTRSKDIIMGVGERLSCRIVAASLRDRGIDSELVSLESIIDWDVLGD
EAEVASKSADGPPQLGQEFYSKLSQRLGERLAECGDRVPVVTGFFGVVPGSLLAQVGRGY
SDLCAALCAVGLSAAELQVWKEVDGIFTADPRKVPTARLLSTITPEEAAELTYYGSEVIH
PFTMEQVIRAAIPIRIKNVENPRGEGTIIFPDTVSADAADETHTAKTTVAPSAAPYAPAS
LPSSVLEPHLGPTAITIKDTVVVLSVHSNRKTISHGFFARIFGALDKHGIVVDLISTSEV
HVSMAIHGEIRKSVLDRVTRDLKVVGEISISRDMAILSLVGKHMKNMVGVAGKMFTTLAE
GNVNIEMISQGASEINISCVIEERDAVKALNLVHLKLLHQAPQVFS