Protein Info for mRNA_6476 in Rhodosporidium toruloides IFO0880

Name: 14844
Annotation: KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2179 transmembrane" amino acids 46 to 66 (21 residues), see Phobius details amino acids 163 to 184 (22 residues), see Phobius details amino acids 193 to 217 (25 residues), see Phobius details amino acids 239 to 258 (20 residues), see Phobius details amino acids 278 to 299 (22 residues), see Phobius details amino acids 422 to 441 (20 residues), see Phobius details amino acids 472 to 494 (23 residues), see Phobius details amino acids 592 to 613 (22 residues), see Phobius details amino acids 619 to 639 (21 residues), see Phobius details amino acids 697 to 721 (25 residues), see Phobius details amino acids 1106 to 1135 (30 residues), see Phobius details amino acids 1197 to 1222 (26 residues), see Phobius details amino acids 1274 to 1292 (19 residues), see Phobius details amino acids 1297 to 1317 (21 residues), see Phobius details amino acids 1385 to 1404 (20 residues), see Phobius details amino acids 1410 to 1429 (20 residues), see Phobius details amino acids 1771 to 1790 (20 residues), see Phobius details PF00664: ABC_membrane" amino acids 570 to 749 (180 residues), 74.2 bits, see alignment E=2.1e-24 amino acids 1171 to 1419 (249 residues), 99.1 bits, see alignment E=5.6e-32 PF00005: ABC_tran" amino acids 819 to 967 (149 residues), 65 bits, see alignment 1.7e-21 amino acids 1490 to 1675 (186 residues), 84.3 bits, see alignment E=1.7e-27

Best Hits

Predicted SEED Role

"ATP-energized glutathione S-conjugate pump, putative"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2179 amino acids)

>mRNA_6476 KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily (Rhodosporidium toruloides IFO0880)
MSMQLILDAAQAGEASDAWCARGTGAEVWDGVDFDPCFRLKVFDGIIPLLFLALSASYLL
VRLFCLARRSFARPSTKYEQLATTDRPSRRSAGSSPIAQAEFRVLREVAEKQSPDWHDPS
TQKELLGDDAEPDVVEADPEAEETGRSGLALAARAVWGCKKDVLNVLANAAMLTFCTLKT
VRAFQLGQGGLAWVAVEMASWAWAFILSVAKVCLAVQHRFFALSHPSLPHRNVSPAYTLL
ERILIPYYVGFASLTGFFDFRSALLGNKTYPYNVSGEALAIEAVLFATSSFLFIVEFFTP
RPSRYSSRSSRTQRRASTTDKSLPSPPEMHASLFSLATFSFLEGFQLRSAFPRVFGAGSI
KMDTIPDLRADDKTARVVLSFRQSMRTLDARLARLPLFVRRRILSDPDAGVEGLGLTPKL
IYHFWPALVAQNIWSLGRVVLNPIAPLMLRRILAHIAKRERGEYAPVHVPILYAWGLFLG
TILGGVCSSQGLFIGRRICIRLRSIIVGEVFTKALRRKDQAGSSSAQPTEEAEVSPSAEA
APKPASKATPAAGSDAEDLDEEELEKELEKASSGKIINLISVDTYRLSEVCAYLHFLLSE
MPLSIIVICYLLFDLLGTSAAVGIAVLTLLVPIQGRISALFNVYQEKLLAAADQRLELTT
EVIGQVRVVKFFAWERKFLEMMDATRKKELSAIWKRALTMVAGNGLMFGAPFIVGSVTFV
FHTKVLERPLTAETAFTALAFLQVLRTPLEGFTDMFVNVLQAYVSLKRLDAFMQEEETHK
YSLLQKATSPEDPVIGFVDGTFTWANEDAARQDPSVFRLKDLNLRFPQGQLSIILGPVGS
GKTTLLQSLLGETNRLSGSAFLPSPVIRSTDCNPAILTETTAYASQQPWLLSATIRENIL
FGSPFNAKRYQATLDACALLPDLKSLELGDDTEVGEKGTVLSGGQKARISLARAIYSPAK
YVLLDDVISAVDSHTAQHLVEKCLTGKVMRHRTCVLVTHAVDLCLPVAGFVVTLDQGAVV
SAGPPDTLSQSRLLELEKHDKFASDANESSFSTIEGLAEGETDEALRQHQEEERRKRAEK
LKLVKDETQSEGAVKKEVYYTYIRAFGGWSVALVALAIFVGAQLADIAISLALRYWANSF
DRKADSFGSVFVSTVAASTGRLHAVSARLAQAARSVSQGDLSASSILGEDRKLDSDYWLA
MYCLLAVVNLAFITARAAFFLWRGLCASRILYRRLISQILGAPIRFFDSTPTGRILNRLS
KDMETIDQDLSQTAMYYTFELVAVAGIIGTVSAAVPAFLLAATVIAAGYWVLGYIYVASS
RELKRFESVTRSPIFSVFGESLQGVSTIRAYGDASRFMRHIFRLLDENNRPFFTLWLANR
WLSLRTDVFGAIAALIAALFVIFARSMDAALAGFVLSFALMFQERLLWIVRLNAQIEVQA
NSVERIQEYLELEQESQGGVHPPAIWPTRGGTISVNKLTASYAPNLPSVLKAVSFEVKGG
EKVGIVGRTGSGKSSLALSFFRFIEPSSGNITIDGIDINTLKLEDLRSRLTIVAQEAALF
AGTLRFNLDPFGQHEDQAIWDALGRVQMAAPGASGITPKPTPGPSRAVSPTNSDDEGSEA
TATAEDERYVVKSLDMPVKEGGKNFSAGQRQLLALARGILKLRSSSILILDESTASLDHA
TDERIQETIRSEMADATILCIAHRLRTVIDYNKILVLDHGVVKEFDTPSNLLADTDSMFS
ALCQKSGEYDVLKKMADDAAKQRGEFHRVSSLSQALASFDIVLIVSLNSFSSTTSRSPAR
RLGTPCYTVWDTVTPTLTARDSPDAPHLSLRWLPRLPRPKRWATSPSGKLWAETLHRYQA
SVPVSPNHEHSKQAEWEAELERQLRFGSKEGGRELEKEYKRQLREVERRAEHAGAENLVR
EVLPVYFVEHGEDVDEGVLASVGAEINSLQPQTIILLAPHDTSVSRLLVSTASTISSAYS
PVLSFTGSPRVASQLIRAFAHTPPLGVPAAGSTLPTLSPRSARVLSAMHLNPDVELVQVL
LPVMQEKEARWGAEKWWDAGRAIHHYLHEMEKDVQQVVGVGKYKREYKNIVVLALGSAAP
KNPSSSFPALLSSALAHHTSHARELSLHSLYSSSSGSKPRKAVRGEAVGLYTAVAAAGEG
EGEMLGRGEVWRLGHLPIR