Protein Info for mRNA_6665 in Rhodosporidium toruloides IFO0880

Name: 15033
Annotation: K01952 purL, PFAS phosphoribosylformylglycinamidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1370 TIGR01735: phosphoribosylformylglycinamidine synthase" amino acids 8 to 1369 (1362 residues), 1665.9 bits, see alignment E=0 PF18076: FGAR-AT_N" amino acids 36 to 172 (137 residues), 121.9 bits, see alignment E=2.8e-39 PF18072: FGAR-AT_linker" amino acids 197 to 249 (53 residues), 75.5 bits, see alignment (E = 7.9e-25) PF02769: AIRS_C" amino acids 469 to 627 (159 residues), 101.5 bits, see alignment E=1.1e-32 amino acids 892 to 1025 (134 residues), 40 bits, see alignment E=9.1e-14 PF13507: GATase_5" amino acids 1107 to 1369 (263 residues), 311 bits, see alignment E=1.1e-96

Best Hits

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1370 amino acids)

>mRNA_6665 K01952 purL, PFAS phosphoribosylformylglycinamidine synthase (Rhodosporidium toruloides IFO0880)
MLVLPGASVFHPPQRAALLARVNANAPQVTSVDAVYIHYVEPVSLAAGKTLADPNSKERK
VLDALLKYGDDYALAETRPAVDLAVEVGNAPGVIWVVPRAGTISPWSSKATDIARMCTLD
GTVQRIERGIAFVIKAEGDAQRVAHLENVAHFLHDRMTQLLLDQKPEAKALFERGSPAPL
KTIDLRDKSVTEAKEKLVKANQELGLALAGDELDYLVESFLASAASGRDPTDVELFMFAQ
VNSEHCRHKIFNAAWVVDGQEKDNSLFAMIRNTHKLTPEHTISAYSDNAAVIDGSVVPRF
AAAPSTAANVPVYQANEEHMPILIKVETHNHPTAVSPFPGAATGSGGEIRDEGAVGRGSR
PKAGLAGFTVSNLLIPDFVQPWETDFGKPAHIASPLDIMIEGPLGSSAFNNEFGRPGLTG
YFRTFAEEIPSLDKDGKPSTEIRGYHKPIMIAGGYGNVRPEFALKDKIEPGARLIVLGGP
GMLIGLGGGAASSMASGSSSADLDFASVQRENPEMQRRCQQVLDTCVSLGAENPVQSVHD
VGAGGLSNALPELVHDADLGGVFEIRDVLVDDPGMSPMEIWCNESQERYVLAVGPENLER
FEAIAKRERCPYAVVGTATTEQKLVVTDRLLGQDAINLPMSLLFGKPPRMHRKAVTLQPP
RNAFDSSLKQYLPLAESTRDLVDLAVERVLHLPSVGSKSFLITIGDRSISGLVARDQMVG
PWQVPVADVAVTSASYGFDVLAGEAMAMGERTPLALLSPAASARMAVAESLLNLAAANTP
SLAHVKLSANWMTAASYNDGNEGAALYEAVQGIGMDLCPALGVSIPVGKDSMSMSMGWND
DAGKRKTVTAPNSLVVTAFSPVTNVDQTWTPELQVVPEPTVLVFFDLANGKQRLGGSALA
QVFKQIGSEAPDVEDPKVLKAFLEGCNRIRAEHPEIVLAYHDRSDGGLFTTVVEMCFAGR
IGAEIMVDAFKKDDDAIAALFNEELGAVFQVRQSDVPAFSQAFIRAGVPSTAIHPIGRVA
SSREDQAVSIASGGALLWSSTRAALQQQWAETSYRMQALRDSPQGALEEFENIARDDNTG
LFYRLSFDPAQNVADPFLEKLTSLNDRPKVAILREQGVNGHIEMAWSFSQAGFAAVDVHM
SDLITGKVSLADFKGIAACGGFSYGDVLGAGNGWAKSILLHDRARQEFSAFFNDRTDTFA
LAVCNGCQLFSQLRELIPGAENWPFFKQNLSGRFEGRVSLVEVVDSPATKDSVFLCDMAG
SILPIAVAHGEGRATFIAPASQEKNAANVVVRYVDPSGQPTERYPYNPNGSPGGITGVQA
LNGRVLAMMPHKERVQVLAANSWYPKEESKKWKRRGPWTRVFESARVWVG