Protein Info for mRNA_6799 in Rhodosporidium toruloides IFO0880

Name: 15167
Annotation: K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 491 PF03446: NAD_binding_2" amino acids 7 to 174 (168 residues), 171.3 bits, see alignment E=2.7e-54 TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 7 to 478 (472 residues), 763 bits, see alignment E=5.7e-234 PF03807: F420_oxidored" amino acids 8 to 103 (96 residues), 22.7 bits, see alignment E=1.9e-08 PF00393: 6PGD" amino acids 181 to 477 (297 residues), 423.9 bits, see alignment E=5.1e-131

Best Hits

Swiss-Prot: 74% identical to 6PGD1_YEAST: 6-phosphogluconate dehydrogenase, decarboxylating 1 (GND1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 83% identity to uma:UM02577.1)

MetaCyc: 67% identical to 6-phosphogluconate dehydrogenase, decarboxylating (Homo sapiens)
Phosphogluconate dehydrogenase (decarboxylating). [EC: 1.1.1.44]

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (491 amino acids)

>mRNA_6799 K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase (Rhodosporidium toruloides IFO0880)
MSQAVADIGLIGLAVMGQNLILNMADKGFTVCAYNRTVSKVDHFLENEAKGKSIVGAHSV
EELCAKLKTPRKIILLVKAGQAVDDFIAQLEPHLEKGDIVIDGGNSHFPDSNRRTKELES
KGLLFVGSGVSGGEEGARYGPSLMPGGSNAAWPHIKEIFQKTAAQTDGEPCCDWVGEEGA
GHYVKMVHNGIEYGDMQLITEAYDILKRGFGMHEKEIADIFERWNKGVLDSYLIEITTQI
LRYNDDDGTPLVAKILDAASQKGTGKWTATNALDLGMPVTLIGEAVFARCLSAIKEERVR
ASKVIGGPQIEPFSGDKKQFIDDLEQALYASKIVSYAQGFMLMREAAKTYGWHLNNAGIA
LMWRGGCIIRSVFLGDITKAYQKNPELENLLFDDFFNKAIHKAQPGWRRIVAQGALWGIP
TPAFSTALSFFDGYRTERLPASLLQAQRDFFGAHTFRVLPQFANEKLKEGQDIHINWTGR
GGNVSASTYNV