Protein Info for mRNA_6808 in Rhodosporidium toruloides IFO0880

Name: 15176
Annotation: K12856 PRPF8, PRP8 pre-mRNA-processing factor 8

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08082: PRO8NT
  • amino acids 34 to 185 (152 residues), 279.1 bits, 3.1e-87
• PF08083: PROCN
  • amino acids 382 to 787 (406 residues), 771.7 bits, E=5.2e-236
• PF10598: RRM_4
  • amino acids 972 to 1062 (91 residues), 159.8 bits, see alignment (E = 5.9e-51)
• PF10597: U5_2-snRNA_bdg
  • amino acids 1196 to 1329 (134 residues), 232.2 bits, 6e-73
• PF10596: U6-snRNA_bdg
  • amino acids 1430 to 1587 (158 residues), 292.8 bits, 2.4e-91
• PF12134: PRP8_domainIV
  • amino acids 1747 to 1976 (230 residues), 413.7 bits, E=7.6e-128
• PF08084: PROCT
  • amino acids 2198 to 2318 (121 residues), 113.9 bits, 1.6e-36

Best Hits

Swiss-Prot: 80% identical to PRP8_MOUSE: Pre-mRNA-processing-splicing factor 8 (Prpf8) from Mus musculus

KEGG orthology group: K12856, pre-mRNA-processing factor 8 (inferred from 80% identity to aml:100483587)

Predicted SEED Role

"Triosephosphate isomerase (EC 5.3.1.1)" in subsystem Calvin-Benson cycle or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or MLST (EC 5.3.1.1)

MetaCyc Pathways

• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (20/22 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/25 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (11/12 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• gluconeogenesis I (11/13 steps found)
• glycolysis I (from glucose 6-phosphate) (10/12 steps found)
• homolactic fermentation (10/12 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• glycolysis IV (8/10 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (12/16 steps found)
• gluconeogenesis III (9/12 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• Calvin-Benson-Bassham cycle (9/13 steps found)
• glycerol degradation to butanol (11/16 steps found)
• glycolysis V (Pyrococcus) (6/10 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
• sucrose degradation V (sucrose α-glucosidase) (2/5 steps found)
• superpathway of hexitol degradation (bacteria) (11/18 steps found)
• ethene biosynthesis V (engineered) (16/25 steps found)
• oxygenic photosynthesis (10/17 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (11/19 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (16/26 steps found)
• superpathway of N-acetylneuraminate degradation (11/22 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (8/21 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (26/57 steps found)

KEGG Metabolic Maps

• Carbon fixation in photosynthetic organisms
• Fructose and mannose metabolism
• Glycolysis / Gluconeogenesis
• Inositol phosphate metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.3.1.1

Use Curated BLAST to search for 5.3.1.1

Protein Sequence (2321 amino acids)

>mRNA_6808 K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 (Rhodosporidium toruloides IFO0880)
MSQEQLAQKERKWRALQAKRFGDKRKTGIIDTGKQPLPAEHLRKIIRDHGDMSNRKFRQD
KRVHLGALKYVPHAVLKLLENMPMPWEQVREVPVLYHITGAITFVNEVPKVIPPVYHAQW
ATMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDTEPLEAIQLELDEEEDAPIA
EWFYDGRPLIDSPHVNGSSYKLWTLDLPQMANLYRFGRTLLSDFNDRNYFYLFEPKSFFT
AKALNVAIPGGPRFEPLFRESDNFDDDWNEFNDINKVIIRQQIRTEYKIAFPHLYNSRPR
SVHIPVYHEPHNLYIRTEDPDLPAFYFDPIIHPISSRGVAPKNELVPHEVEVFGGDSNGE
DDEFELPEECEPFLADAELETDRTADAIALWWAPYPYNQRSGRTVRAQDIPLVKNWYLEH
CPPGQPVKVRVSYQKLLKCYVLNQLHHRHPKPQIKKSLFKQLKGTKFFQTTTIDWVEAGL
QVCRQGYNMLNLLIHRKNLNYLHLDFNMNLKPVKTLTTKERKKSRFGNAFHLCREILRLT
KLIVDSHVQYRLGNVDAFQLADGLQFTFAHVGQLTGMYRYKYKLMRQIRMCKDLKHVIYT
RFNTGPVGKGPGVGFWAPGWRVWLFFLRGIVPLLERWLGNLLARQFEGRNSKGVAKTVTK
QRVDSHFDLELRAAVMHDILDMMPEGIKQNKAKTILQHLSEAWRCWKANIPWKVPGMPTA
IENIILRFVKAKADWWTSVAHYNRERIRRGATVDKTVAKKNLGRLTRLYLKAEQERQNAY
LKDGPYVSSEEAVAIYSATVHWLESRKFAPIPFPPLSYKHDTKLLVLALEKLKEAYSVKG
RLNQSQREELALIEQAYDNPHETLSRIKRLLLTQRAFKEAGIEFFDTYDKLIPCYDIEPI
EKITDAYLDQFLYFEADKRGLFPSWIKPADTEPPPLLVYKWCQGINNLHEVWETSEGECN
VMMETQLSKVYEKIDLTLLNRLLRLIMDHNLADYCTAKNNIVITYKDMSHVNAYGLIRGL
QFSGFIFQYYGLILDLLILGLQRASEMAGPPQMPNNFLQYRDTETETRHPIRLYSRYIDR
IHIMFRFTADESRDLIQRYLSANPDPNNENLIGYNNKKCWPRDCRMRLIKHDVNLGRAVF
WDIKNRLPRSLTTIDWDDTFVSVYSKDNPQLLFSMSGFEVRILPKIRNVNEVFTLKDGVW
NLVHGGTKERTAQAFLRVSNPGIEAFNNRIRAILMSSGSSPFSKVINKWNTAIIGLMTYY
REAVIHTNELLDVLVKAENKVQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMLSMGHIL
IPASDLRWSKQTDTGITHFRAGMGGGNSEVLIPNLFRYIQPWEAEFLDSARVWSEYAMKR
KEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRNRIEWKQYQLLKANPF
WWTSQRHDGKLWQLNNYRVDVIAALGGVEGILEHTLFKATAFPTWEGLFWEKSSGFEESM
KFKKLTNAQRSGLSQVPNRRFTLWWSPTINRANVYVGFQVQLDLTGVFMHGKIPTLKISL
IQIFRAHLWQKIHESVVMDLCQVFDQELEALQIETVQKETIHPRKSYKMNSSCADILLFS
SYKWNVTRPSLLTDSKDVMDGTTSAKYWVDVQLRWGDFDSHDIERYTRAKFLDYTSDNMS
IYPSPTGVLIGIDLAYNLHSAYGNWIPGMKPLVQQAMGKVMKANPALYVLRERIRKSLQL
YSSEPTEPYLNSQNYSELFSNQIIWFVDDTQVYRVTIHKTFEGNLTTKPINGAIFIFNPR
TGQAFIKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLE
VHLLDFPNIVIKGSELQLPFQACMKLEKFGDLILRATQPQMVLSNMYDDWLKSISSYTAF
SRLILLLRAIHVNNEKAKIILRPNKNTVTEPHHVWPTLADEDWMRVEIALRDLILADYGK
RNSVNTASLTSSEVRDIILGMEIQAPSVQRQQMAEIEKSTEAAAQVTAVQTRTTNVQGDE
IQVVTTTAYEQQVFSSKTDWRIRAISATNIPLRLQHVYVTNDDVKEELPTFVLAKNIMKS
FVTSADLRAPVAAYLFGQVAPDNARVVEVKAVAVVPQRSSQRSIELVNDLPSHPLLADLK
VVGIIATQAQETQSLTPADACLFAKLMAQHSEIDGSSIFLTVAFTPGSLSLAAYALTPKG
FEWGRNADPNSPAGYNPASMVDRAQLLLSDRILGSTFAPVGGVWSYSTGLGAAFSPTMPY
SVTLVGQPMPYWAPEHRPAHFSQFVAGADMDEGVDAEDAFA