Protein Info for mRNA_6908 in Rhodosporidium toruloides IFO0880

Name: 15276
Annotation: K01907 AACS, acsA acetoacetyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 659 TIGR01217: acetoacetate-CoA ligase" amino acids 7 to 649 (643 residues), 568.3 bits, see alignment E=9.1e-175 PF00501: AMP-binding" amino acids 111 to 519 (409 residues), 130.6 bits, see alignment E=6.5e-42

Best Hits

Predicted SEED Role

"Acetoacetyl-CoA synthetase (EC 6.2.1.16)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism or Polyhydroxybutyrate metabolism (EC 6.2.1.16)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.16

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (659 amino acids)

>mRNA_6908 K01907 AACS, acsA acetoacetyl-CoA synthetase (Rhodosporidium toruloides IFO0880)
MPSTRTLFWTPTAQDIDDAPDTKFRLWVNQRHNLKLRNYDELHAWSITALDAFWTAVYDY
CGVIGERTDPNTFFDASKPMETINRQLIRANMNYAEPKSMSSNDLDDCLMRSLTFEELYQ
QVRFVAHTLRTKFDIKPGDRVATFSPSNAEAVVLCLATLAVGGVWSSCPSEFGVTAVLER
LEQIEPKVLLTADYYKYNGKNFPVYTKLEEILAKLPSVKNVIVVGQLSHDREPQVEYPAD
KQGKTWMSWNEMVRLGKDAPAEIQFERVSAMDPVWILYSSGTTGKPKAIVHSVGGMILGQ
KMVHLSTHVFTSISPRSVLGCGACMAAFDGSPFSPSASTIWALAEKHKITILGLSPRYLQ
TLETNGYIPNKEFDLRHVKQVQTAGSVLKPELYDWMRLNIHKDVWVNNGTGGTDICSLFI
GAVRSKPIYHGELTCMALGMDLQAWDEDGNPVIDGQGDMVITKPFPNMPIGFWGPGGEKR
YHAAYFEAYPQKQPAVWTHGDWIEIHSLTKGVLVLGRSDGVLNPAGVRFGSAEIYNVVEE
IEEVEDCLAIGQKLLDGDERFILFVKPKQTPLGQSVTDKIKLAIRTSLSPRHVPAKIIEL
VKIPYTTNGKRLEVTAKKLVNGHDYAKLNLSSAEDPECLKVFVDHPELRLVDVPEKSKL