Protein Info for mRNA_7872 in Rhodosporidium toruloides IFO0880

Name: 16240
Annotation: K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 618 PF02146: SIR2" amino acids 154 to 387 (234 residues), 184.8 bits, see alignment E=1.4e-58

Best Hits

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (618 amino acids)

>mRNA_7872 K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1 (Rhodosporidium toruloides IFO0880)
MDPDSSVAQPLPAAQLAPPGPALTTFPAPVPNYQDLTDESPSEDDEQDWDALVSAVERNF
SEQQIDDMHEFLKERGLFAFLREYLERRSVPPSTLLLAFGVMIRPDLPMNDQLRMLKIAC
SRVLRNRDKLMEYNTPQDVVDLIRKSKRILILTGAGVSTSCGIPDFRSSTGLYARLREQN
SLWDLDDPQDMFDLAYFKRSPNVFYSFAKEIYPSNFVPSPCHRFVRLLEMEGKLLRNYTQ
NIDGLFEQVGVERMLNCHGSFATASCLICRRRFPGTAIEPDVFSSRVPLCPFCTPELEAA
AATLAREREERPKKKRKVGREEWEGSEGSEEEDSGEGRSEWEGKALIKPDIVFFGEALSD
EFDHRLLEDREEVDLLIVMGTSLRVSPVAQLPSHLPHSIPQILINRDPLPHQNFDVCLLG
DGDTIVRWLCEELGKSTLPEEAGETKKEEYEKQWDLDSRVPVHVPEHKLPPLPSDAPLDD
PAPSHPSLPATTPSTSSIHPEQVGHSHVWLFPGASRESRWVQSVRVAYGSDRESEDGEDK
GPVELPASLAPGVIEGEGSDGSDDSDLEDESSSGKQEGGPSNGLQEKATVEENGVAGNAL
QPPLPPTDLKPEQHQYTQ