Protein Info for mRNA_7912 in Rhodosporidium toruloides IFO0880

Name: 16280
Annotation: K11434 PRMT1 type I protein arginine methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 344 PF02353: CMAS" amino acids 58 to 131 (74 residues), 24.4 bits, see alignment E=6e-09 PF06325: PrmA" amino acids 60 to 135 (76 residues), 42.3 bits, see alignment E=2.3e-14 PF13489: Methyltransf_23" amino acids 60 to 115 (56 residues), 30.2 bits, see alignment E=1.4e-10 PF13847: Methyltransf_31" amino acids 62 to 165 (104 residues), 40 bits, see alignment E=1.3e-13 PF05175: MTS" amino acids 62 to 135 (74 residues), 23.1 bits, see alignment E=1.8e-08 PF13649: Methyltransf_25" amino acids 66 to 163 (98 residues), 47 bits, see alignment E=1.3e-15 PF08241: Methyltransf_11" amino acids 67 to 165 (99 residues), 36.4 bits, see alignment E=2.4e-12

Best Hits

Swiss-Prot: 65% identical to ANM1_SCHPO: Protein arginine N-methyltransferase 1 (rmt1) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)

KEGG orthology group: K11434, protein arginine N-methyltransferase 1 [EC: 2.1.1.-] (inferred from 70% identity to cne:CNB03520)

MetaCyc: 65% identical to protein arginine N-methyltransferase 1 (Homo sapiens)
RXN-16889 [EC: 2.1.1.319, 2.1.1.320, 2.1.1.321]

Predicted SEED Role

"Protein arginine N-methyltransferase 1 (EC 2.1.1.-)" in subsystem Dimethylarginine metabolism (EC 2.1.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.-

Use Curated BLAST to search for 2.1.1.- or 2.1.1.319 or 2.1.1.320 or 2.1.1.321

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (344 amino acids)

>mRNA_7912 K11434 PRMT1 type I protein arginine methyltransferase (Rhodosporidium toruloides IFO0880)
MQVDSTTTNATTAAPVPVEGATSADYYADSYAHFGIHEEMLKDEVRTLSYRNAMWHNKHL
FKDKVVLDVGCGTGILSMFAAKAGAKKVIGVDMSNIIDQAQKIVAANGFADTITLIKGKM
EEVVLPVDKVDIIISEWMGYFLLYESMLDSVLYARDRYLVPDGLMFPDEATMYIAAIEDQ
EYKEEKIGFWEDVYGFDYSCIKEIALREPLVDTVDLKSVVTNPCKLATFDLLTVKKEELT
FASQFKLVATRNDYVHAFLGWFDCAFRACHKPVSFSTGPHAKYTHWKQTVFYLTDMVTLQ
TNDSIEGVITVSPNARNPRDLDIVIDYKVDGQHPHQERREYRMA