Protein Info for mRNA_8034 in Rhodosporidium toruloides IFO0880
Name: 16402
Annotation: K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K00898, pyruvate dehydrogenase kinase [EC: 2.7.11.2] (inferred from 64% identity to ang:ANI_1_544024)Predicted SEED Role
"Enolase (EC 4.2.1.11)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or Serine-glyoxylate cycle (EC 4.2.1.11)
MetaCyc Pathways
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (20/22 steps found)
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/25 steps found)
- Bifidobacterium shunt (14/15 steps found)
- superpathway of aromatic amino acid biosynthesis (16/18 steps found)
- superpathway of L-tyrosine biosynthesis (10/10 steps found)
- superpathway of L-tryptophan biosynthesis (12/13 steps found)
- glycolysis III (from glucose) (10/11 steps found)
- chorismate biosynthesis I (7/7 steps found)
- superpathway of L-phenylalanine biosynthesis (9/10 steps found)
- gluconeogenesis I (11/13 steps found)
- chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
- glycolysis I (from glucose 6-phosphate) (10/12 steps found)
- homolactic fermentation (10/12 steps found)
- glycolysis II (from fructose 6-phosphate) (9/11 steps found)
- Rubisco shunt (8/10 steps found)
- glycolysis IV (8/10 steps found)
- superpathway of glucose and xylose degradation (13/17 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (12/16 steps found)
- gluconeogenesis III (9/12 steps found)
- superpathway of anaerobic sucrose degradation (14/19 steps found)
- gallate biosynthesis (2/3 steps found)
- quinate degradation I (2/3 steps found)
- quinate degradation II (2/3 steps found)
- Entner-Doudoroff pathway I (6/9 steps found)
- glycerol degradation to butanol (11/16 steps found)
- chorismate biosynthesis II (archaea) (8/12 steps found)
- glycolysis V (Pyrococcus) (6/10 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (18/27 steps found)
- heterolactic fermentation (11/18 steps found)
- superpathway of hexitol degradation (bacteria) (11/18 steps found)
- ethene biosynthesis V (engineered) (16/25 steps found)
- Entner-Doudoroff pathway II (non-phosphorylative) (4/9 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (4/9 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (11/19 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (16/26 steps found)
- formaldehyde assimilation I (serine pathway) (6/13 steps found)
- superpathway of N-acetylneuraminate degradation (11/22 steps found)
- gluconeogenesis II (Methanobacterium thermoautotrophicum) (8/21 steps found)
- superpathway of chorismate metabolism (28/59 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (26/57 steps found)
- superpathway of aromatic compound degradation via 3-oxoadipate (4/35 steps found)
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate (5/42 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Glycolysis / Gluconeogenesis
Isozymes
Compare fitness of predicted isozymes for: 4.2.1.11
Use Curated BLAST to search for 2.7.11.2 or 4.2.1.11
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (446 amino acids)
>mRNA_8034 K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 (Rhodosporidium toruloides IFO0880) MVFSFTEALKRQIAHYASFPQTGVSLRQMVMFGQNPSQGTLLRASQFLADELPIRLAHRV KELDELPHGLHKMPSIEKVKRWYAQSFEELVSFPRPELPQHLSEALLRASQESECIPEPV PNPSLPEHMKPRPNQLKSKQGRQKMPLHRYYSNPDQNIVWPPEVHDYNERFTRLLSNIKR RHDPVVTTVAQGILEFKRERKSPHIDRSIQTFLDRFYMSRIGIRVLIGQHIALNRLEPHE DYVGIICTRTNVHQIAREAIENATYVCEEHYGLFKGPPVQLICPKDLNFMYVPSHLNHVL FEVLKNSLRAVVETHGVDCEDYPPVKVIVAEGNEDITIKISDEGGGIPRSALPLVWTWMY TTANPENLDQDFQGTDFKAPMAGFGYGLPIARLYAQYFGGNLKLISMEGYGTDCYIHLSR LSQSSEPLQLKGHASGVDANPNIINF