Protein Info for mRNA_8327 in Rhodosporidium toruloides IFO0880
Name: 16695
Annotation: K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 51% identical to MKAR_USTMA: Very-long-chain 3-oxoacyl-CoA reductase (UMAG_04441) from Ustilago maydis (strain 521 / FGSC 9021)
KEGG orthology group: K10251, beta-keto reductase [EC: 1.1.1.-] (inferred from 58% identity to scm:SCHCODRAFT_57944)MetaCyc: 40% identical to very-long-chain 3-oxoacyl-CoA reductase (Saccharomyces cerevisiae)
RXN-13298 [EC: 1.1.1.330]; 1.1.1.330 [EC: 1.1.1.330]; 1.1.1.330 [EC: 1.1.1.330]; 1.1.1.330 [EC: 1.1.1.330]; 1.1.1.330 [EC: 1.1.1.330]
Predicted SEED Role
No annotation
MetaCyc Pathways
- very long chain fatty acid biosynthesis I (1/4 steps found)
- arachidonate biosynthesis III (6-desaturase, mammals) (2/7 steps found)
- icosapentaenoate biosynthesis II (6-desaturase, mammals) (2/7 steps found)
- icosapentaenoate biosynthesis III (8-desaturase, mammals) (1/7 steps found)
- (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) (4/13 steps found)
- docosahexaenoate biosynthesis III (6-desaturase, mammals) (4/14 steps found)
- very long chain fatty acid biosynthesis II (4/16 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Aminosugars metabolism
- Ascorbate and aldarate metabolism
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of type II polyketide products
- Biosynthesis of unsaturated fatty acids
- Bisphenol A degradation
- Butanoate metabolism
- C21-Steroid hormone metabolism
- Fructose and mannose metabolism
- Glycine, serine and threonine metabolism
- Insect hormone biosynthesis
- Linoleic acid metabolism
- Nucleotide sugars metabolism
- Polyketide sugar unit biosynthesis
- Retinol metabolism
- Tetrachloroethene degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.-
Use Curated BLAST to search for 1.1.1.- or 1.1.1.330
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (347 amino acids)
>mRNA_8327 K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase (Rhodosporidium toruloides IFO0880) MDVATLRAQAIDWADAVLSPPASDCPLTTLAFAVLGAGWLGSYVLSFARMVVDLARPGIP LKRFGAKKGAWAVVTGATAGIGRDFALQLAAAGFNIFLASRTASKLDEIAQEITAKYPSV KTQIHAIDFSSASADYAALKAALDPLDVGVLINNVGKSYEEPTFFQDLSDQDMIDIVEIN VNATMKVTKLVIPGMVSRKRGLILTVGSFASLIPSPLLAVYSGSKAFLSTWSQALGSELK GTGVEVELLNTYFVVSKLSKIRKSSWMIPTPKTYVRSVLSHIGVRGGAVGQPHISTPYHG HAPVQWVVDHLFSRHFWLDYNRKLHLDIRKRALRKREREAAKAVKGE