Protein Info for mRNA_8393 in Rhodosporidium toruloides IFO0880

Name: 16761
Annotation: K12385 NPC1 Niemann-Pick C1 protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1548 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 284 to 305 (22 residues), see Phobius details amino acids 484 to 508 (25 residues), see Phobius details amino acids 768 to 804 (37 residues), see Phobius details amino acids 874 to 899 (26 residues), see Phobius details amino acids 905 to 925 (21 residues), see Phobius details amino acids 976 to 995 (20 residues), see Phobius details amino acids 1001 to 1026 (26 residues), see Phobius details amino acids 1079 to 1097 (19 residues), see Phobius details amino acids 1345 to 1363 (19 residues), see Phobius details amino acids 1369 to 1391 (23 residues), see Phobius details amino acids 1398 to 1425 (28 residues), see Phobius details amino acids 1449 to 1471 (23 residues), see Phobius details amino acids 1483 to 1506 (24 residues), see Phobius details PF16414: NPC1_N" amino acids 35 to 283 (249 residues), 253.9 bits, see alignment E=3.5e-79 PF02460: Patched" amino acids 867 to 1139 (273 residues), 126.7 bits, see alignment E=1.8e-40 amino acids 1280 to 1505 (226 residues), 92.7 bits, see alignment E=3.7e-30 PF12349: Sterol-sensing" amino acids 870 to 1043 (174 residues), 150.2 bits, see alignment E=8.5e-48 PF03176: MMPL" amino acids 1271 to 1409 (139 residues), 25.8 bits, see alignment E=1e-09

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1548 amino acids)

>mRNA_8393 K12385 NPC1 Niemann-Pick C1 protein (Rhodosporidium toruloides IFO0880)
MLSSTLRLVCLAVAVVPVVFALSEDATPTFVREEGRCAMRDSCGRKSVFSGEIPCPDNGL
ATAHDDDLAYKALLAGICGEDFPTTTCCTTGQLETLQANLAQADPLISACPACRLNFRRF
FCSFTCSPNQSLFLTVTSTQTLKKDGKDREAVKSVDFAVAEQFGEGFFDACKDVKFGATN
GFAMDLIGGGAKDWLSFLRYMGQERALGSPFQIDIPSPDSPPSQNTTLSPPTPFNAPSES
CSSTSLTSRCACPDCPAVCASLPPLLSPREKWERRCRVGKMDCFPFALLIVYAVAVLAVV
FGGVGREVRRRMGSKGGAIRLGDEESDTGTGESESLLTRLIGRLNPSHLFTPTSTGRPRR
STLNGSDTEYSASPLPLDSAPRNDDLLSEAEYDPSPAPLASNSPPLSRSTPRTGDSSAGS
SSTRARGGTVGSASSRLLRRTDESSRSSRGASLLDPAADSSALLQPRSYPLNTFLSRAFY
RLGFFCSTHPFIVLAIGLAVCGLANAGWARFEIEKDPVELWVPKGSEVRREKEAFEKAFG
PFYRTEQIFFSVAPPVRLRLVDGREEEEEQDWTPIDQPVLSWPVLQYILDVETQIRTLAS
SSSGLTLEDVCFAPTTSAEDGKTALSVDECVVQSPLGYFQNSLEGVTEDSWASQLDSCTS
SPASCLPPFGQPLNPKLVLGGVPEGAANHDARAVIITYVVRNSVDPIEVARAQEWETALR
NYLRQLADPQSEARRDYGLKVSWSVGTSLEEELNAATNTDVPIVVTSYFLMFAYVAVSLG
GSATGLVKVLGRIAVLIGAALMRLARWVAKRAKALSGRGGVKLGDDEAEEGAGRPGRFRT
ASAAMSDGFGSTTRPRKDSLVAYFKKQVLVDSKFLLGLWGILIVLLSVSTSVALCSAGGV
KTTLIIAEVIPFLVLAIGVDNVFLLSHELDQQNVRSYRENSLLMPGEEYEDEVVAEPSLP
AEERVARALGRMGPSILLSASCQTLAFSLGALVGMPAVRNFAIYAAVAVLLNALLQITVF
VAAMAIDLRRVESNRIDCFPCIKVSNITAIVHSAHPTESLLAHLVRTVYTPTLLRRPVKY
LVLLLFSGLFILSWIGARHIELGLDQRLALPGSSYLVDYFNAVDEYLDVGPPVYFVVENL
NVTALPNVRHLCGRFSTCDQFSLANSLEAERKRPAVSYLAEPPAVWVDDFVQWLNPLLED
CCRVKRRNPDEFCGPNDSESLCKPCFEDREPPWNTTLEGLPEDDEFMRYVAHWLESPTDE
ACPLGGKAGYSSALAISKDGENVDLSHFRTYHTPLKTQDDFINALAAARRIAADLAKRTG
ARVFPYSLFYVFFSSYDTIRSTSRMVLFIALVVVFAVTAALLGSLRTASVVICTVFLSLF
SVLGAMGVWGVSLNPLSLVNLVIAIGIAVEFCAHIARAFVGALGGGLPRSHPQAQRDRDE
RARTALEDVGASVMSGIGATKLIGISVLWLTRSALLKTYYARIWLALIVSSAVHGLVFLP
VALSLWGSQGYALTAEEGDGAWIATSVESRYQDRPFVDDDASSGDSEY