Protein Info for mRNA_271 in Rhodosporidium toruloides IFO0880

Name: 8639
Annotation: K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2233 PF00289: Biotin_carb_N" amino acids 60 to 181 (122 residues), 98.7 bits, see alignment 1.2e-31 PF02786: CPSase_L_D2" amino acids 230 to 413 (184 residues), 179.9 bits, see alignment E=2e-56 PF02222: ATP-grasp" amino acids 232 to 383 (152 residues), 20.6 bits, see alignment 1.1e-07 PF07478: Dala_Dala_lig_C" amino acids 242 to 382 (141 residues), 21.5 bits, see alignment 5.9e-08 PF02785: Biotin_carb_C" amino acids 457 to 563 (107 residues), 71.5 bits, see alignment 2.4e-23 PF00364: Biotin_lipoyl" amino acids 702 to 766 (65 residues), 52.7 bits, see alignment (E = 1.3e-17) PF08326: ACC_central" amino acids 769 to 1482 (714 residues), 820.9 bits, see alignment E=4.1e-250 PF01039: Carboxyl_trans" amino acids 1575 to 2131 (557 residues), 572.8 bits, see alignment E=2.6e-175

Best Hits

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase domain of homomeric ACCase (EC 6.4.1.2) / Biotin carboxyl carrier domain of homomeric Acetyl-CoA carboxylase / Biotin carboxylase domain of homomeric ACCase (EC 6.3.4.14)" (EC 6.3.4.14, EC 6.4.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2233 amino acids)

>mRNA_271 K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 (Rhodosporidium toruloides IFO0880)
MPFSGEAKAVNGSHSVDEAPKNPKYDHGRVVKYLGGNSLESAPPSKVADWVRERGGHTVI
TKILIANNGIAAVKEIRSVRKWAYETFGSERAIEFTVMATPEDLKVNADYIRMADQYVEV
PGGTNNNNYANVDVIVDVAERAGVHAVWAGWGHASENPRLPESLAASKHKIVFIGPPGSA
MRSLGDKISSTIVAQHAQVPCMDWSGQGVDQVTQSPEGYVTVADDVYQQACVHDADEGLA
RASRIGYPVMIKASEGGGGKGIRKVEKEQDFKQAFQAVLTEVPGSPVFIMKLAGAARHLE
VQVLADQYGNAISLFGRDCSVQRRHQKIIEEAPVTIAKPDTFEQMEKSAVRLAKLVGYVS
AGTVEFLYSAADDKFAFLELNPRLQVEHPTTEMVSGVNLPAAQLQVAMGVPLHRIRDIRT
LYGKAPNGSSEIDFDFENPESAKTQRKPSPKGHVVAVRITAENPDAGFKPSMGTLQELNF
RSSTNVWGYFSVGSAGGLHEFADSQFGHIFAYGSDRSESRKNMVVALKELSIRGDFRTTV
EYLIKLLETDAFEQNTITTAWLDSLISARLTAERPDTTLAIICGAVTKAHLASEANIAEY
KRILEKGQSPAKELLATVVPLEFVLEDVKYRATASRSSPSSWSIYVNGSNVSVGIRPLAD
GGLLILLDGRSYTCYAKEEVGALRLSIDSRTVLIAQENDPTQLRSPSPGKLVRYFIESGE
HISKGEAYAEIEVMKMIMPLIAAEDGIAQFIKQPGATLEAGDILGILSLDDPSRVHHAKP
FDGQLPALGLPSIIGNKPHQRFAYLKDVLSNILMGYDNQAVMQSSIKELISVLRNPELPY
GEANAVLSTLSGRIPAKLEQTLRQYIDQAHESGAEFPSAKCRKAIDTTLEQLRPAEAQTV
RNFLVAFDDIVYRYRSGLKHHEWSTLAGIFAAYAETEKPFSGKDGDVVLELRDAHRDSLD
SVVKIVLSHYKAASKNSLVLALLDIVKDSDSVPLIEQVVSPALKDLADLDSKATTKVALK
AREVLIHIQLPSLDERLGQLEQILKASVTPTVYGEPGHDRTPRGEVLKDVIDSRFTVFDV
LPSFFQHQDHWVSLAALDTYVRRAYRSYNLLNIEHIEADAAEDEPATVAWSFRMRKAASE
SEPPTPTTGLTSQRTASYSDLTFLLNNAQSEPIRYGAMFSVRSLDRFRQELGTVLRHFPD
SNKGKLQQQPAASSSQEQWNVINVALTVPASAQVDEDALRADFAAHVNAMSAEIDARGMR
RLTLLICREGQYPSYYTVRKQDGTWKELETIRDIEPALAFQLELGRLSNFHLEPCPVENR
QVHVYYATAKGNSSDCRFFVRALVRPGRLRGNMKTADYLVSEADRLVTDVLDSLEVASSQ
RRAADGNHISLNFLYSLRLDFDEVQAALAGFIDRHGKRFWRLRVTGAEIRIVLEDAQGNI
QPIRAIIENVSGFVVKYEAYREVTTDKGQVILKSIGPQGALHLQPVNFPYPTKEWLQPKR
YKAHVVGTTYVYDFPDLFRQAIRKQWKAAGKTAPAELLVAKELVLDEFGKPQEVARPPGT
NNIGMVGWIYTIFTPEYPTGRRVVVIANDITFKIGSFGPEEDRYFFAVTQLARQLGLPRV
YLSANSGARLGIAEELVDLFSVAWVDSSRPEKGFKYLYLTAEKLGELKNKGEKSVITKRI
EDEGETRYQITDIIGLQEGLGVESLKGSGLIAGETSRAYDDIFTITLVTARSVGIGAYLV
RLGQRAVQVEGQPIILTGAGALNKVLGREVYSSNLQLGGTQIMYKNGVSHLTAANDLEGV
LSIVQWLAFVPEHRGAPLPIMPSPVDPWDRSIDYTPIKGAYDPRWFLAGKTDEADGRWLS
GFFDKGSFQETLSGWAQTVVVGRARLGGIPMGAIAVETRTIERIVPADPANPLSNEQKIM
EAGQVWYPNSSFKTGQAIFDFNREGLPLIIFANWRGFSGGQQDMFDEVLKRGSLIVDGLS
AYKQPVFVYIVPNGELRGGAWVVLDPSINAEGMMEMYVDETARAGVLEPEGIVEIKLRKD
KLLALMDRLDPTYHALRVKSTDVSLSPADAAQAKTELAAREKQLMPIYQQVALQFADSHD
KAGRILSKGCAREALEWSNARRYFYARLRRRVAEEAAVKRLGDADPTLSRDERLAIVHDA
VGQGVDLNNDLAAAAAFEQGAAAITERVKLARATTVASTLAQLAQDDKEAFAASLQQVLG
DKLTAADLARILA