Protein Info for mRNA_344 in Rhodosporidium toruloides IFO0880

Name: 8712
Annotation: K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 894 PF00792: PI3K_C2" amino acids 70 to 196 (127 residues), 106.6 bits, see alignment E=1.6e-34 PF00613: PI3Ka" amino acids 297 to 515 (219 residues), 176.2 bits, see alignment E=7.4e-56 PF00454: PI3_PI4_kinase" amino acids 618 to 823 (206 residues), 142.3 bits, see alignment E=3.8e-45

Best Hits

Predicted SEED Role

"Phosphatidylinositol 3-kinase (EC 2.7.1.137)" (EC 2.7.1.137)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.137

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (894 amino acids)

>mRNA_344 K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase (Rhodosporidium toruloides IFO0880)
MPLESGLDSLAHPGSASCDSQISFLKHGDLAQLVAIKVASFEGHIPQRPLTDLLDHPELK
HHGFQQQLPSDLFVRVELWADNKPLIPPVQTAHKAFKSRTQIDWNEHITLPIKYRDLPLG
SQLAVTVYDIAGPGELAVVGGSTLRLFGNKCTLKKGKQRLFLWKGKEADGSVETETPSKV
GLKDEMGRLEKLAESEKSENLFLYIDLPRFDFPVVFCEPEYPLPVLSSLTLSSTAVPPST
STATAQGSSTSAGTSAQQAAEASLFTIVDPEIVRKNPVEAKHRRLVRDHRNGPLDRELKP
NAKIRDELNEILRYPPTQELTTPQRDLLWKFRFYLTRDKRALTKFLKSVVWSDPGEAKQA
VETLLPMWSEIEMDDALELLGPAEGFRDRRVRAYAVRQLERADDEELMLYLLQLVQALKF
EPASSSTSPTSSHVSPSASLRHSHAHIHRHGSSLRPTAASPHDSLPTLEDFLVERSAKNP
VLGNHFYWYIQVEREAKARGSMFEGVARNFERRMQELQQEGEPDRLETLRRQSEFIARIT
QLASSLRLSKDARPKKIEKLRSAIHSSSTGLSSFSSPIPLPLDARVSITGIDAETSSVFK
SNLFPLRLQLLTTSGEPYPVIFKNGDDLRQDQLVIQLFTLMDRLLRKENLDLKLMPYRVL
ATGALDGMVQFVPSRTLQDITFEYGAQGLLGYLRENHADPGSVGTYDVKPEVLDTYIRSC
AGYCVVTYLLGVGDRHLDNLLLSPDGHFFHVDFGYILGRDPKPFPPAVKVCKEMVDAMGG
MHSPHYARFKSLCYTGFTTLRKNANLLINLVALMVDGNIPDIKLEPDKAVMKADLIFSSS
SGTHSGPPPQVQDKFLLNLTEEEAIKEFEALLNDTSYFTSVLDRIHSVAQYWRS