Protein Info for mRNA_491 in Rhodosporidium toruloides IFO0880

Name: 8859
Annotation: K00850 pfkA, PFK 6-phosphofructokinase 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00365: PFK
  • amino acids 7 to 82 (76 residues), 68.3 bits, E=3.8e-23
  • amino acids 163 to 436 (274 residues), 255.9 bits, E=2.5e-80

Predicted SEED Role

"6-phosphofructokinase (EC 2.7.1.11)" in subsystem D-Tagatose and Galactitol Utilization or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 2.7.1.11)

MetaCyc Pathways

• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (20/22 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (22/25 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• glycolysis I (from glucose 6-phosphate) (10/12 steps found)
• homolactic fermentation (10/12 steps found)
• glycolysis II (from fructose 6-phosphate) (9/11 steps found)
• glycolysis IV (8/10 steps found)
• sedoheptulose bisphosphate bypass (2/2 steps found)
• formaldehyde assimilation II (assimilatory RuMP Cycle) (7/9 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (12/16 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• 1,3-propanediol biosynthesis (engineered) (5/9 steps found)
• galactitol degradation (2/5 steps found)
• D-galactosamine and N-acetyl-D-galactosamine degradation (1/4 steps found)
• lactose and galactose degradation I (1/4 steps found)
• superpathway of hexitol degradation (bacteria) (11/18 steps found)
• N-acetyl-D-galactosamine degradation (1/5 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (11/19 steps found)
• superpathway of N-acetylneuraminate degradation (11/22 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Fructose and mannose metabolism
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Pentose phosphate pathway

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.11

Use Curated BLAST to search for 2.7.1.11

Protein Sequence (519 amino acids)

>mRNA_491 K00850 pfkA, PFK 6-phosphofructokinase 1 (Rhodosporidium toruloides IFO0880)
MACDPSQSHRDEGKRKTIVIVAEGAHDCNLNPITPNDIKDVLTNRLGLDTRVTTLGHTQR
GGNPVAYDRILATLQGAEAVEAVLSSNPSTPSPVIGIRENKITRRPLMEAVAQTQEVAKA
IEAKDFTRALSLRDPEFEDCLHAFRATTRLNTEYRVPESQRMRIGIIHTGAPAGGMNAAT
RTAVRYCLCHGHTPVAIYNGFAGLLEGNVAELTWLRVDQWGTRGGSELGTNRALPDSDME
GIAAKLAEYKIDSLFIVGGFEAMVAVNQLDKARDRYKALKIPLVHLPATISNNVPITEWS
IGSDTSINVLVDACDAIKQSATASRNRVFVVETQGAGCGYIAMLGALASGANIVYTPENG
ITLKQLVDDVEFLKRRYQQDVAGKSEGRLVIRSEKASKTYTTEVISNILAEEGKDLFDSR
LVSLGHTLQGGCIDWLEQQHGSKTPGAASIAIQGAEIRFVPIAEMIAAADTKHRRGKVQW
WTPMQRLVDVLCGRINLENEPLNAGIVPLAATTTATQTS