Protein Info for mRNA_1093 in Rhodosporidium toruloides IFO0880

Name: 9461
Annotation: K08734 MLH1 DNA mismatch repair protein MLH1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 736 TIGR00585: DNA mismatch repair protein MutL" amino acids 17 to 334 (318 residues), 316 bits, see alignment E=1.9e-98 PF13589: HATPase_c_3" amino acids 39 to 137 (99 residues), 51.7 bits, see alignment E=1.6e-17 PF02518: HATPase_c" amino acids 40 to 97 (58 residues), 29.1 bits, see alignment 2.4e-10 PF01119: DNA_mis_repair" amino acids 239 to 354 (116 residues), 109.2 bits, see alignment E=2.1e-35 PF16413: Mlh1_C" amino acids 490 to 736 (247 residues), 266.5 bits, see alignment E=5.5e-83

Best Hits

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (736 amino acids)

>mRNA_1093 K08734 MLH1 DNA mismatch repair protein MLH1 (Rhodosporidium toruloides IFO0880)
MERMATEKPAAPPAPRAIAKLPEAVVNRIAAGEIIQRPSNALKELIENSLDAGATTIRVT
VKEGGLKLLQIQDNGSGIRKSDLPILCERFTTSKIKAFEDLSSLGTYGFRGEALASISHV
AHLSVTTKTRDETCAWKAAYADGALIPLKPGGDAAPLPCAGNDGTVLTVEDLFYNTPQRL
RSLRPANEEYARILSVVTAYSIHNAGVSFVCKKTSSSSSSTGDVNTSIGASTLDNIGVLY
GEAVRRELVEVQAVSEELGVKVRAWCSGANYQAKRSTFLFFINHRYVDCTSLKRALEAFY
STLLAKNTHPFVYLSLSISPSKIDVNVHPTKKEVAFEDEDEVVQLVCEKLAEVLEKQGES
RSYKVQTLLPTSGTPTAPRTLAGSSATATPAASTSRKPSTSSSTKPAKVAPNKLVRTDAQ
SQTLDAMFPTLPTTSTIRAGDKTREAADDQDRSSKKRKSDHNPAFASQLAAEQAAQKSAR
VRIAQSECALTSVRQLRKEVVEARHEGLDALIKGHIFVGVADLETCKSMIQHQTKLYIVD
HAAIGEELFYQLGLRHFGRFSRIKLQPPQDLRKLVQLAVDRASGGGAGNPAPPKIVERVF
STLHGARAMLDEYFSFSISDDGKIESLPLVLPGYSPDMNKLPLFLLRIGAHVDWEHEKPC
FATFLRELAFFYSPAPSPTAPPAPHSQDQVDAQKRTIQHVLFPAAKQYLVPPEKLLKKDV
VLATSLEALFRVFERC