Protein Info for mRNA_1127 in Rhodosporidium toruloides IFO0880

Name: 9495
Annotation: K00143 LYS2 L-aminoadipate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03443: L-aminoadipate-semialdehyde dehydrogenase
  • amino acids 9 to 1496 (1488 residues), 1994.4 bits, E=0
• PF00668: Condensation
  • amino acids 109 to 322 (214 residues), 32.1 bits, E=1.9e-11
• PF00501: AMP-binding
  • amino acids 345 to 813 (469 residues), 241.2 bits, E=5.8e-75
• TIGR01733: amino acid adenylation domain
  • amino acids 376 to 836 (461 residues), 390.5 bits, E=1.3e-120
• PF00550: PP-binding
  • amino acids 970 to 1034 (65 residues), 41.3 bits, see alignment (E = 5.6e-14)
• PF01370: Epimerase
  • amino acids 1092 to 1305 (214 residues), 30.9 bits, E=7.1e-11
• TIGR01746: thioester reductase domain
  • amino acids 1092 to 1469 (378 residues), 321.6 bits, E=1.1e-99
• PF01073: 3Beta_HSD
  • amino acids 1094 to 1359 (266 residues), 29.1 bits, E=1.8e-10
• PF07993: NAD_binding_4
  • amino acids 1094 to 1347 (254 residues), 236.1 bits, E=1.3e-73

Predicted SEED Role

"L-aminoadipate-semialdehyde dehydrogenase large subunit (EC 1.2.1.31)" in subsystem Lysine degradation (EC 1.2.1.31)

MetaCyc Pathways

• L-lysine degradation VI (2/3 steps found)
• L-lysine degradation IX (1/2 steps found)
• L-lysine degradation VIII (1/2 steps found)
• L-lysine degradation XI (mammalian) (3/5 steps found)
• L-lysine degradation V (3/9 steps found)
• L-lysine degradation II (L-pipecolate pathway) (2/9 steps found)
• superpathway of L-lysine degradation (11/43 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis
• Lysine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.31

Use Curated BLAST to search for 1.2.1.31

Protein Sequence (1504 amino acids)

>mRNA_1127 K00143 LYS2 L-aminoadipate-semialdehyde dehydrogenase (Rhodosporidium toruloides IFO0880)
MADSSLLQRWLARLSDLPQLALPTDYPRPSGENALSMVEAREVRQLDNRTGASLLRLSLY
DEHEGESDDDESDADDDADSHSNCKGIDAALAQAAAGGGKSRRDRQRPTAFHILLAAFAV
LLHRYTGDTDLVIATSSPSSPEPLLLRIKLDPADSFWSLVKRIQFLENEAEEDKIPYETL
LDALPGYGKEAQREGGPAPPPVFRVRFFDQTDSPDSSFVQQTSLTSDLTVFVSTTPTDEP
SAAQTPGSTSGTATPTTPSSLRTSLTFTPPRISLTLSYNSLVFSQPRISLTIDQLLHVLH
HVSAHPQDAIGSFSLLTSKQRRILPDPKADLEWCGYRGAITDIFSNNARRFPDRVCIVES
IASDEVGGKNGERRFTYRQIDEASNVLAHHLVQSGVQREEVVTVYSTRGVDLVVAVMGVL
KAGATFSVIDPAYPPARQTIYLQVAQPRALVILAAAGKLLPPVRQYVSEKLSIRVEVPAL
QLTSSGLVLGSVASTSEKEKDVFAAVQERASEPLGIPLGPDSVGTLSFTSGSTGIPKGVR
GRHFSLTHFFPWMRERFGLSEESRFTMLSGIAHDPIQRDIFTPLFLGASLYIPTAEDIGT
PGRLAEWMADNAVTVTHLTPAMGQLLSAQATRLIPSLLNAFFVGDILTKRDCTRLQQLAQ
NCRIINMFGTTETQRAVSYFPIPPLSEDPIFLRTRKDIMPAGQGMINVQLLVVNRADKNQ
ICAVGEVGEIYVRSGGLAEGYLQLPDATREKFVENWFGAGVEREDSIRNSNEPWKEWWHG
VRDRMYRTGDLGRYNPDGTVECTGRADDQIKIRGFRIELGEIDTHLSRHPAVRENVTLVR
RDKYEEKVLVAYFVPLVGSKELEGLVSGDEDEDDADSKRDGNKVSQNEVAKGLRRYGRLI
KNIREYLKTKLPSYSVPSVIVPLARMPLNPNGKVDKPALPFPDTVAAAASSVAGPSSGSS
TQKLTPTEKTIHDIWLKLLPSPPAEIPLDDSFFDLGGHSILATRLIFELRKSLVPGAPLG
LVFDYPTIRSLAKELDSLRDADLGLGAGSNAASGSAANGAVDTEYSDDAEALTKTLRASY
EKPQPSEGKKVVFLTGATGFLGAFILRDLLALDRRGGQVTKVICHVRAGSKEKAMQRLRE
SGEGRGAWEEKWVEEGRLEVVVGDLEGEKLGMSEEDWQRVAQEADVIVHNGAIVHWVYPY
KQLRAANVLATLAVIELAATSRPKALSFVSTTAAIEKAHYVRLADSIVQAGGKGVPESDS
LDAGKVGLKGGYGQSKWVSERLVLEAGRRGLAGSIVRPAYIVGDSTSAVTNTDDFLWRLV
KGCIQLGHIPDIHNTINMVPVDHVARITACAALQDPSTDLKVHHVTARPAPRFNGFLAAL
KLYGYNVATTEYLPWRTLLEQHVLRVQDNALFPLLHFVLDDLPTSTKAAELDDSNTVALL
KGARQPEAVTVDDAQMGRYLAWLIAAGFLEQPPRKGEQGVRPLPQLELQAGGARAIGRSS
AGVV