Protein Info for mRNA_1206 in Rhodosporidium toruloides IFO0880

Name: 9574
Annotation: K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1313 transmembrane" amino acids 25 to 46 (22 residues), see Phobius details amino acids 231 to 249 (19 residues), see Phobius details amino acids 255 to 276 (22 residues), see Phobius details amino acids 293 to 318 (26 residues), see Phobius details amino acids 324 to 341 (18 residues), see Phobius details amino acids 416 to 434 (19 residues), see Phobius details amino acids 440 to 465 (26 residues), see Phobius details amino acids 543 to 562 (20 residues), see Phobius details amino acids 665 to 685 (21 residues), see Phobius details amino acids 1242 to 1266 (25 residues), see Phobius details PF02460: Patched" amino acids 257 to 498 (242 residues), 21.4 bits, see alignment E=9.5e-09 PF12349: Sterol-sensing" amino acids 401 to 467 (67 residues), 36.2 bits, see alignment 8e-13 TIGR00533: hydroxymethylglutaryl-CoA reductase (NADPH)" amino acids 866 to 1275 (410 residues), 540.2 bits, see alignment E=1.5e-166 PF00368: HMG-CoA_red" amino acids 895 to 1275 (381 residues), 461.2 bits, see alignment E=3.9e-142

Best Hits

Predicted SEED Role

"Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.34)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.1.1.34)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1313 amino acids)

>mRNA_1206 K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) (Rhodosporidium toruloides IFO0880)
MVFATSPSSFSSLRLPILRLAKLGTAYPIEVIVTLFCAATLVYFQLIKVVRHSDFLLYDD
DVFPSANTLNRHPSISFEPSTGLWTSVSPSEPAPIDTVELWLRQVIVEVPNTMAVARKNE
VKELLEADSLLAEQGIEDCYKVAGQCWKVQTQPALNLTVKSFAFESLVGPTQFFANFSTL
PLETETVALEKVRRSQGRKRYTSFFNRGQDDFVVEGSDQPSEDRKREMESVHWVLFAAKV
FVLRFWGLAKKADSADIFVMLIAYVLMHSTFVSLYLNMRRLSRSLRPNSNSLGFWLATLS
LASSCVAFMFALLTAWYLEISVNPVLLGEALPFLVITVGFEKPFVLTRAVFSNPAIGPGG
AYAGAASRGTSTPSGNGKLVTPTTNAFGLRFSPPVPARDIVLSAVSKTGVPIVRDYAIEI
AVLVLGAMSGVAGLREFCQLAAVILVWDAFCLIGFFVAVLTIMVEIHRIKVVRHFRRTDS
SADLSRLLDDPNAFRDADAQASDDEEEAPTPTLTLREKLIKLSTGTAPGAKATSGSPTAR
LKVLLIAAFLTLHSLNLVTTLTAKTALGRHIDHSASTSHIPHIDTSNPVLSSTLLQLVAA
HEAGTKLLVHIVPALHFHAVDRTLPPAPAVSTAQAALPHLTAATGSFGSIDQFFTRWSRL
VGDPIVSKWIVIALGLSLFLNGYLLKGIASGSDSFGHGSAAEVAARILLASTGSDVDNDD
DEAAKARLRRSFSLLREELQNEWTQKDAAVMQREYARHELKAEREAGKTAPTVVKVSAAK
PRRDSDSSDESAPGSPILIRTRKALNGAPPSSTLTVPSPDEATAPQLKLSPSTVALVSQN
GIPDTPRDLDTCVKIFNGGEGAMLLNDEEIIMLVQKGKLAAYALEKLLKDYVRAVSIRRA
LISRASARKTLEASDLPFLHFDYSRVMGQCCENVVGYMPIPVGIAGPLRIDGNVLPIPMA
TTEGALVASTSRGCKALNVSGGVTTVVTQDAMTRGPALDFPSVIMCAAAKRWVDSDEGSN
ILKAAFNSTSRFARLKSLKTAMAGRTLFVRFATQTGDAMGMNMISKGCERALDVMMTEHF
PEMKIASLSGNYCTDKKPAAINWIEGRGKSVVAEGIIPGEAVKSILKTTVSDLVRLNITK
NLIGSAMAGSVGGNNAHASNILTAIYLATGQDPAQNVESSNCMTLMEAINDGKDLLITCS
MPSIEVGTVGGGTILLPQAAMLDMLGVKGPHPTSPGQNAQQLARVVCAAVMAGELSLMSA
LAAGSLVQSHLAHNRSAPATPAAQTPQIGSRATTPVLNGTQRLAPLTVTKGKD