Protein Info for mRNA_1520 in Rhodosporidium toruloides IFO0880

Name: 9888
Annotation: K00765 hisG ATP phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 303 TIGR00070: ATP phosphoribosyltransferase" amino acids 15 to 202 (188 residues), 156.1 bits, see alignment E=9.4e-50 PF01634: HisG" amino acids 60 to 224 (165 residues), 183.4 bits, see alignment E=3.1e-58 TIGR03455: ATP phosphoribosyltransferase, C-terminal domain" amino acids 206 to 302 (97 residues), 97.4 bits, see alignment E=4.7e-32 PF08029: HisG_C" amino acids 228 to 300 (73 residues), 93.5 bits, see alignment E=7e-31

Best Hits

Swiss-Prot: 60% identical to HIS1_YARLI: ATP phosphoribosyltransferase (HIS1) from Yarrowia lipolytica (strain CLIB 122 / E 150)

KEGG orthology group: K00765, ATP phosphoribosyltransferase [EC: 2.4.2.17] (inferred from 67% identity to lbc:LACBIDRAFT_292479)

Predicted SEED Role

"ATP phosphoribosyltransferase (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (303 amino acids)

>mRNA_1520 K00765 hisG ATP phosphoribosyltransferase (Rhodosporidium toruloides IFO0880)
MLDLLSESLKGRCLFAIPKKGRLYEKCLQLLAGADIQFTRSHRLDVCLVRNHNMALVFLP
AADIPRFVGEGNVHFGITGQDMVAEADVNGLVSETLQLEFGKCKLQVQVPERGDIKTVED
LVGKKVVTSFEVLAGRYFGELDVKSAKEGVKTKIEYIGGSVEAACALGLADGIVDLVESG
ETMRAAGLHAIETILTSQAVLIRSNKPSDEHDALIQRITSRIAGVVAAGKYVLCNYNIPR
KVVQEATRVTPGRRAATVSPLDDPEWVAVSSMVLKAQVADVMDKLQAIGASDILVIGLNN
CRV