Protein Info for mRNA_1644 in Rhodosporidium toruloides IFO0880

Name: 10012
Annotation: K00253 IVD, ivd isovaleryl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 436 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF02771: Acyl-CoA_dh_N" amino acids 51 to 163 (113 residues), 122.8 bits, see alignment E=2.2e-39 PF02770: Acyl-CoA_dh_M" amino acids 167 to 266 (100 residues), 86.6 bits, see alignment E=2.2e-28 PF00441: Acyl-CoA_dh_1" amino acids 278 to 425 (148 residues), 135.3 bits, see alignment E=4.2e-43 PF08028: Acyl-CoA_dh_2" amino acids 300 to 405 (106 residues), 49.3 bits, see alignment E=1.3e-16

Best Hits

Swiss-Prot: 64% identical to IVD_PONAB: Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) from Pongo abelii

KEGG orthology group: K00253, isovaleryl-CoA dehydrogenase [EC: 1.3.99.10] (inferred from 72% identity to ppl:POSPLDRAFT_103127)

MetaCyc: 63% identical to isovaleryl-CoA dehydrogenase subunit (Pseudomonas aeruginosa PAO1)
RXN0-2301 [EC: 1.3.8.4]

Predicted SEED Role

"Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)" (EC 1.3.8.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.4 or 1.3.99.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (436 amino acids)

>mRNA_1644 K00253 IVD, ivd isovaleryl-CoA dehydrogenase (Rhodosporidium toruloides IFO0880)
MTHYVPRLLRTTTLAARPALAASARTLPTRPAVASSRPVSTTASSAGLGLTEDQLELRET
VASFAQREIAPIAAEVDRKNEFPMEMWEKLGEMGLLGVTVKEDDGGLGKGYLDHLIVMEE
ISRASGSIALSYGAHSNLCVNQLNRHGTLEQKAKFLPNLLSGKFVGSLAMSETGSGSDVV
SMKLKATKTTREGEEGWVLNGGKMWITNGPDADVLIVYAKTEPEAGSKGITAFIVEKGFK
GFSTAQKLDKLGMRGSNTGELVFEDCFVPASNVLGKLNKGVGVLMSGLDLERIVLSGGPL
GLMQAAFDYALPYVHERKQFGVPIGTFQLMQGKIADMYTKVSASRAYLYSVARACDAGQV
TNRDCAGAILYSSDRATEVCLEALQMLGGNGYTNDYEVNRFLRDALLYKVGAGTQEIRRM
LIGREFNNDYADAGAL