Protein Info for mRNA_1924 in Rhodosporidium toruloides IFO0880

Name: 10292
Annotation: K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01514: nicotinate phosphoribosyltransferase
  • amino acids 12 to 437 (426 residues), 377.7 bits, E=3.5e-117
• PF17767: NAPRTase_N
  • amino acids 16 to 147 (132 residues), 117.3 bits, E=6.1e-38
• PF04095: NAPRTase
  • amino acids 181 to 438 (258 residues), 182.9 bits, E=8.1e-58

Best Hits

KEGG orthology group: K00763, nicotinate phosphoribosyltransferase [EC: 2.4.2.11] (inferred from 46% identity to scm:SCHCODRAFT_238844)

Predicted SEED Role

"Nicotinate phosphoribosyltransferase (EC 2.4.2.11)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation or Redox-dependent regulation of nucleus processes (EC 2.4.2.11)

MetaCyc Pathways

• NAD salvage pathway I (PNC VI cycle) (6/7 steps found)
• NAD salvage pathway V (PNC V cycle) (4/5 steps found)
• superpathway of NAD biosynthesis in eukaryotes (10/14 steps found)
• NAD salvage (plants) (6/11 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.11

Protein Sequence (454 amino acids)

>mRNA_1924 K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase (Rhodosporidium toruloides IFO0880)
MANASPPPECYIQSLLDVDLYKLSMQYAVLEKYPHVNVKYRFTNRSGTKFTRTMYDAVLA
AIKHLETLRLQPAERAFLERRCPYFPKSYLDYLSDFRLRPDEQVKVDFVPNGEKDADGTE
WGGFDLEIHGLWTETILYEVPLMSIISEAYFTHVDTKWDYVGQFENARQKGLALYRAGCI
LSEFGSRRRRTYKAHDIVMRGLIKANEECGNGKEGKGGKLSGTSNVHFAQKYDLAPIGTI
AHELIMGIAALEGYEGSNGRMMDMWEKIYPDGSLGIALTDTFTTKPFFDDFVSNPERARR
WKGLRQDSGDPFKFIPVAKEAFQRVGADPSKKIVVFSDSLDVKRCLELKKASDEAGIGCS
FGVGTDLTNDFRHVEQPEQQEHLGDGPIRTEGAKSKALNMVIKLYSINDQFCVKISDELT
KNTGDPEAVRLVKRRFGLEDHGAESDAAKWGPTV