Protein Info for mRNA_2248 in Rhodosporidium toruloides IFO0880

Name: 10616
Annotation: K01338 lon ATP-dependent Lon protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 743 transmembrane" amino acids 623 to 638 (16 residues), see Phobius details TIGR00763: endopeptidase La" amino acids 270 to 715 (446 residues), 611.5 bits, see alignment E=1.5e-187 PF00004: AAA" amino acids 275 to 413 (139 residues), 82.4 bits, see alignment E=1.2e-26 PF07724: AAA_2" amino acids 275 to 398 (124 residues), 23.9 bits, see alignment E=1.3e-08 PF07728: AAA_5" amino acids 275 to 410 (136 residues), 40.8 bits, see alignment E=6.7e-14 PF05362: Lon_C" amino acids 508 to 716 (209 residues), 241.3 bits, see alignment E=2.4e-75 PF13541: ChlI" amino acids 552 to 683 (132 residues), 31.9 bits, see alignment E=3.1e-11

Best Hits

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (743 amino acids)

>mRNA_2248 K01338 lon ATP-dependent Lon protease (Rhodosporidium toruloides IFO0880)
MGTLPVSATGGVTHSDKLLILSTADASARVEEALEILSRVDEALKLSKRIDDKVDKNVAR
RQREYVLMQQLLAIRQELDDLAAEDGRTGNASSSPAQPKGVPAAPRRKHEDEDDIAELEK
KIEAKAFSAEARKVAMRELKRLKKSPPQGAEHGVIRTYLETLLSLPWTSADSTPISLSKD
FVAQARKKLDEDHYGLDKIKKRLLEWLAVLRLQQQQWDATLAASASAQSAAPAAITDAAV
TETAVVVRDPATPPPPAIPAPSTIPARPPYKAPILLLHGPPGVGKTSIARSLAEAMGRKF
VRISLGGVRDESEIRGHRRTFVASMPGKIVNALRRCGTNNPVILLDEIDKLGHASLHGDP
SAAMLEVLDPEQNAHFEDHYLGVPIDLSQVLFIATANSLDTISEPLYDRMEAIELSGYIH
DEKLHIARQSLLPKQLRANALTPSLISLSDETILYLITHYTREAGVRSLERQIGSVCRAK
AVEYAEARDAVKGENKEGEVPEGYKVEVTKEDIERMLGPSRFDPDELEKEARIGVVNGLA
YQGSGNGGILHIETTSHPGTGAFHLTGSLGDVISESAHVAFAWVKAHAYELGISHARDED
VFKRLDVHLHLPAGAVKKDGPSAGVAMVVALVSLMRGIAPRKGIAMTGEITLRGAVTPVG
GIREKVLAAHRAHLTRLILPMHNKRDVESDLPSSVREEIDFVFVERVEEVVEAAFEGGWR
GFTTGGGGGGGGGEVWQERESRL