Protein Info for mRNA_2354 in Rhodosporidium toruloides IFO0880

Name: 10722
Annotation: K01580 E4.1.1.15, gadB, gadA, GAD glutamate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 560 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details TIGR01788: glutamate decarboxylase" amino acids 72 to 506 (435 residues), 619.6 bits, see alignment E=1.3e-190 PF00282: Pyridoxal_deC" amino acids 103 to 442 (340 residues), 250.4 bits, see alignment E=2.6e-78

Best Hits

Swiss-Prot: 51% identical to DCE_PETHY: Glutamate decarboxylase (GAD) from Petunia hybrida

KEGG orthology group: K01580, glutamate decarboxylase [EC: 4.1.1.15] (inferred from 57% identity to nfi:NFIA_059440)

Predicted SEED Role

"Glutamate decarboxylase (EC 4.1.1.15)" in subsystem Acid resistance mechanisms (EC 4.1.1.15)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.15

Use Curated BLAST to search for 4.1.1.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (560 amino acids)

>mRNA_2354 K01580 E4.1.1.15, gadB, gadA, GAD glutamate decarboxylase (Rhodosporidium toruloides IFO0880)
MRIAHRGTFPTYPQSREEEVTRLRPLSLFLLTLFLAAQTRTATRTMSGLHRVPADSRVHD
NPTEDHHVSSTIYGSRQAAQGIPRFEMAEDEMDPRLAQRFVKDELLMNGNPAMNLASFVT
TFQEAEAEELMKENLSINFIDVEEYPAMGEIESRCVNMIARLFNAPLHDETAEAVGVSTI
GSSEAIILAVLAAKRRWKNKRIAEGKSTDKPNIVMSSAVQVCWEKAARYLEVEEKYWYCR
PGKYTIDPQEVVDLVDENTVLVVGILGTTYTGQYEDIETLNDLLDKKNKEKGLNCTIHVD
AASGGFVVPFVNPSLKWDFRLPLVSSINTSGHKYGLVYAGVGWAFWRSKEYLPEEILFTV
NYLGSPQVSFTLNFSKSAIQVVGQYYQLLRLGKAGYRAIMQNLVQIADHLSDAVANMEDG
KLFEIISEGHGQSLPLVAFKLKEEKPYDEFAIASHMRQRGWIIPAYTLAPHTEKIKVLRV
VVREDLSRSRCDTLIRDLKATIDYLEKAPAEVQKHLSNKSQAAGETTSKHHAVAHRNRHA
VELHEKHSLGGKYGKTHAVC