Protein Info for mRNA_2804 in Rhodosporidium toruloides IFO0880

Name: 11172
Annotation: K10808 RRM2 ribonucleoside-diphosphate reductase subunit M2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00268: Ribonuc_red_sm
  • amino acids 44 to 311 (268 residues), 399.2 bits, E=5.3e-124

Best Hits

Swiss-Prot: 74% identical to RIR2_NEUCR: Ribonucleoside-diphosphate reductase small chain (rnr-2) from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

KEGG orthology group: K10808, ribonucleoside-diphosphate reductase subunit M2 [EC: 1.17.4.1] (inferred from 80% identity to scm:SCHCODRAFT_83117)

MetaCyc: 66% identical to ribonucleoside-diphosphate reductase small subunit A (Arabidopsis thaliana col)
Ribonucleoside-diphosphate reductase. [EC: 1.17.4.1]; 1.17.4.1 [EC: 1.17.4.1]; 1.17.4.1 [EC: 1.17.4.1]; 1.17.4.1 [EC: 1.17.4.1]; 1.17.4.1 [EC: 1.17.4.1]

Predicted SEED Role

"Ribonucleotide reductase of class Ia (aerobic), beta subunit (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)

MetaCyc Pathways

• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
• superpathway of purine nucleotide salvage (14/14 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (21/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (15/18 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (7/9 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (5/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (10/14 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (5/8 steps found)

KEGG Metabolic Maps

• Glutathione metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.4.1

Use Curated BLAST to search for 1.17.4.1

Protein Sequence (376 amino acids)

>mRNA_2804 K10808 RRM2 ribonucleoside-diphosphate reductase subunit M2 (Rhodosporidium toruloides IFO0880)
MDGKDKKGDGRDDWLDADGRPRFVGNSSIRSDADEPILRETDRRFVLFPIKYHEVWAAYK
KAEASFWTAEEMDISKDLWDWDRLTDNERHFISHVLAFFAASDGIVNENLVERFSAEVQI
AEARCFYGFQIMMENIHSEVYSLLIETYIREPLEREKLFNAIETIPCIAKKAEWALRWIS
DPRAVFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACL
LFSHLERRPAPHRVAQIIAEAVEIEQEFLTDALPVGLIGMNATLMRQYIEFVADRLLVAL
GNEKLYNAENPFDFMEMISMEGKTNFFEKRVSDYQKSGIMTRVNAMSRTASIADTAGSGA
STPFDERGSLTFDADF