Protein Info for mRNA_3351 in Rhodosporidium toruloides IFO0880

Name: 11719
Annotation: K12196 VPS4 vacuolar protein-sorting-associated protein 4

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 542 PF04212: MIT" amino acids 8 to 72 (65 residues), 77.5 bits, see alignment E=2.1e-25 PF05496: RuvB_N" amino acids 169 to 239 (71 residues), 22 bits, see alignment E=3.7e-08 PF00004: AAA" amino acids 171 to 300 (130 residues), 142.8 bits, see alignment E=2.6e-45 PF17862: AAA_lid_3" amino acids 325 to 357 (33 residues), 30.7 bits, see alignment (E = 6.5e-11) PF09336: Vps4_C" amino acids 382 to 442 (61 residues), 91.1 bits, see alignment E=1.1e-29

Best Hits

Swiss-Prot: 65% identical to VPS4_CANAL: Vacuolar protein sorting-associated protein 4 (VPS4) from Candida albicans (strain SC5314 / ATCC MYA-2876)

KEGG orthology group: K12196, vacuolar protein-sorting-associated protein 4 (inferred from 68% identity to cci:CC1G_13597)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (542 amino acids)

>mRNA_3351 K12196 VPS4 vacuolar protein-sorting-associated protein 4 (Rhodosporidium toruloides IFO0880)
MSNNSNFLDKACEIVKQAIDADVKQEWNEAFKLYKNSLDYFNMAYKYEKNPKLKDLIRSK
VEEYLERAEKLKDHIQASEAKAKADAQGGGKAVSGGGGGAQAKKGTGEDDDADTKKLRDG
LSSAILSETPNVRWEDVAGLEQAKESLKEAVILPIKFPHLFTGKRTPWRGILLYGPPGTG
KSFLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVKQLFAMAREHAPSIIFIDEIDSLC
GTRGEGESEASRRIKTEFLVQMNGVGNDQSGVLVLGATNIPWALDVAIKRRFEKRIYIPL
PDPAARVKMFHLNIGTTPCQLSQADYRKLAEMTDGYSGSDLAVVVRDALMQPVRKVLSAT
HFKEVPVPVEAEDGSSQTVRKLTPCSPGDKGAKEMTWNDVNSDELLEPPLTYNDFVRAVQ
SAKPTVTQEDIKQHLIFAQEGGSECEFSPADCAFEVCGICAKCADGSLNLSRISHSPHCR
SRISPGVHAASTADRNSPPFSSHRSFASPGLIRPSPSLYCFSACWQVSSYHLSDLLRLSE
QS