Protein Info for mRNA_3577 in Rhodosporidium toruloides IFO0880

Name: 11945
Annotation: K04567 KARS, lysS lysyl-tRNA synthetase, class II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 604 TIGR00499: lysine--tRNA ligase" amino acids 143 to 592 (450 residues), 535.7 bits, see alignment E=5.4e-165 PF01336: tRNA_anti-codon" amino acids 180 to 258 (79 residues), 42 bits, see alignment E=1.1e-14 PF00152: tRNA-synt_2" amino acids 277 to 591 (315 residues), 191.4 bits, see alignment E=3.3e-60 PF01409: tRNA-synt_2d" amino acids 369 to 430 (62 residues), 20 bits, see alignment E=6.5e-08

Best Hits

Swiss-Prot: 58% identical to SYK_MOUSE: Lysine--tRNA ligase (Kars) from Mus musculus

KEGG orthology group: K04567, lysyl-tRNA synthetase, class II [EC: 6.1.1.6] (inferred from 65% identity to cci:CC1G_02312)

Predicted SEED Role

"Lysyl-tRNA synthetase (class II) (EC 6.1.1.6)" (EC 6.1.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (604 amino acids)

>mRNA_3577 K04567 KARS, lysS lysyl-tRNA synthetase, class II (Rhodosporidium toruloides IFO0880)
MLLRPSNLFRTLAARPSLRPPLATFAVRPYSQPPRKPSNKMADVTTPDVPQNKQQGAAAD
APNLQKDPETGEMVSKSELKKRMKARELAKKKAEKAAKAPAQPAAKTNAADDEEELSPNQ
YYEIRSRAIQKLRAIPASERTLTTPNPYPHKFHVTISIPSFIDKYGKECKEPGSKSEDVV
SVAGRIHSMRAQGAKLRFYDLWSEGTKIQVMATANDSESPEEFEALHNLFRRGDILGVTG
HPMRTKRSELSISPKSCVLLSPNLHQLPKEHFGFKDQEQRHRKRYLDLIMNQDRREVFIK
RARIINYVRKFLDNLGFLEVETPMMNQIAGGATAKPFITHHNALNLDLYMRVAPELYLKE
LVVGGLDRVYEIGRVFRNEGIDLTHNPEFSICEFYMAYADMYDLMDLTESMISGLVKHIT
GGYKIKYHPEGKEGPEMELDFSTPWKRFNMIEELEKQLGVTFPPGDQLDSPETNKFLRDL
CTKHNVDCSEPRTNARLLDKLVGEFIENQCISPSFIVGHPQVMSPLAKHHRSIKGLCERF
EVFVATREICNAYTELNDPFIQRANFEAQMQQKAQGDEEAQGYDETFVRTFSSNTAVRGR
GSRR