Protein Info for mRNA_3594 in Rhodosporidium toruloides IFO0880

Name: 11962
Annotation: K01555 FAH, fahA fumarylacetoacetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 TIGR01266: fumarylacetoacetase" amino acids 3 to 422 (420 residues), 378.1 bits, see alignment E=2.7e-117 PF09298: FAA_hydrolase_N" amino acids 16 to 119 (104 residues), 71.7 bits, see alignment E=5.4e-24 PF01557: FAA_hydrolase" amino acids 131 to 419 (289 residues), 149.3 bits, see alignment E=1.4e-47

Best Hits

Swiss-Prot: 38% identical to FAAA_DICDI: Fumarylacetoacetase (fah) from Dictyostelium discoideum

KEGG orthology group: K01555, fumarylacetoacetase [EC: 3.7.1.2] (inferred from 38% identity to ddi:DDB_G0271094)

Predicted SEED Role

"Fumarylacetoacetase (EC 3.7.1.2)" in subsystem Homogentisate pathway of aromatic compound degradation or Salicylate and gentisate catabolism (EC 3.7.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.7.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (428 amino acids)

>mRNA_3594 K01555 FAH, fahA fumarylacetoacetase (Rhodosporidium toruloides IFO0880)
MQSWLDIPADSHFSLANVPFGIISHAGSGGARVAATRLGDLAADLSLIEAAGLLAEAFEQ
KETSFFAKPTLNDFAGLPAKIRQNVRLSIQSLFASNSSLPDDLRSRAVISLDSVETHLPF
SIPDFVDYSIFPAHALGAGRAIFGPQNQMPPAWNALPMAYNGRAGTVSVKNEIVRPQGQT
RAFSAAREVAVGPCQALDWEFEIGAFVAEPTEDGTVLTPSTAASRIFGFVLLNDWSARDI
QAFEMVPLGPFNGKSFATTISPWVVVPEALEPFATVKPPRLEGTAFEEPEYLREKEGAKT
NYEVECTTTLHLASNPSTAEPVAKASFVQAFWSFSQLLTYQTYSGARLQTGDLLGSGTIS
NMGDRAQGCMLELSQGGKVPLRIGGEERRWIEDGDEVVFSAVAGGEGRKVGFGELRGKVL
PMTTLRMA