Protein Info for mRNA_3605 in Rhodosporidium toruloides IFO0880

Name: 11973
Annotation: K01872 AARS, alaS alanyl-tRNA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 957 TIGR00344: alanine--tRNA ligase" amino acids 15 to 936 (922 residues), 933.1 bits, see alignment E=8.9e-285 PF01411: tRNA-synt_2c" amino acids 15 to 596 (582 residues), 714.5 bits, see alignment E=1.3e-218 PF07973: tRNA_SAD" amino acids 696 to 754 (59 residues), 62.3 bits, see alignment 5.3e-21 PF02272: DHHA1" amino acids 811 to 952 (142 residues), 48.7 bits, see alignment E=1.7e-16

Best Hits

Swiss-Prot: 64% identical to SYA_CANAL: Alanine--tRNA ligase (ALA1) from Candida albicans (strain SC5314 / ATCC MYA-2876)

KEGG orthology group: K01872, alanyl-tRNA synthetase [EC: 6.1.1.7] (inferred from 66% identity to scm:SCHCODRAFT_82606)

Predicted SEED Role

"Alanyl-tRNA synthetase (EC 6.1.1.7) @ Alanyl-tRNA synthetase (EC 6.1.1.7), mitochondrial" (EC 6.1.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (957 amino acids)

>mRNA_3605 K01872 AARS, alaS alanyl-tRNA synthetase (Rhodosporidium toruloides IFO0880)
MSATASQFGDWPATKVRQTFLDYFTEQNGHSFVKSSSTIPYEDPTLLFANAGMNQYKSIF
LGTVDPSSPFSKLKRAANSQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKE
ATAMAWNLLTQVYGLPPSRLYVTYFEGGFGLPADLETKNLWLALGVPEDHIIPGNAKDNF
WEMGATGPCGPCTEIHYDRIGGRNAASLVNMDDPDVLEVWNVVFIQYNREADSSLRELPA
KHVDTGMGFERLVSVLQDKRSNYDTDVFRPLFDKIQQLTNARAYEGKLGKDDVDGIDTAY
RVVADHVRTLTFAICDGGVPSNVGRGYVLRRVLRRGARYVRKKFGVPIGSFFSSLVPTLV
EQMGGFFPEITGKFEDLKEILDEEEESFARTLDRGEKLFESYVQQAKKEGSNTLRGADVW
RLYDTYGFPVDLTLLMAEEAGLSIDQAAFEAAQEASKEASKGAGKKGDGQAVRLDVHDIA
ALEANADVPKTNDEAKYGTGNVDSVVKAIYRQGKFVASTEELEDAQQVQLGIVLDRTNFY
AESGGQEYDTGRIVIDGQADFVVEDVQVFNGYVLHIGRVVEGALKVGDKVVSSYDELRRW
PLRNNHTGTHILNYCLREVLGDHVDQKGSLVAPSKLRFDFSHKSPIPTAELDRIEDMSNE
WIKRNVKVFSKEMDLSTAQKIPGLRAVFGEAYPDPVRVVTLEFSLEEIQADIENPKWRST
SVEFCGGTHVQKTGEIKEFVITEESGIAKGIRRIIAITGEDARKASQLANDSEARFEQII
KLDLVEKEKQLKAFELEVATLTVSVGRRDRLKQRIAAERKAIVDAARAAEKEQGKAVADE
VDRFFKENPDAKIMVARLDAAKGNPKVIQSAISQAKTLSKAGYFFSATEDGTKVAHLNVL
PKGEISKEFNAKTWFNAVAAIVGGKGGGKDDGAQGFGDKADKIDEAIVEAKKLYESR