Protein Info for mRNA_3621 in Rhodosporidium toruloides IFO0880

Name: 11989
Annotation: K00252 GCDH, gcdH glutaryl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 58 to 169 (112 residues), 94.4 bits, E=1.5e-30
• PF02770: Acyl-CoA_dh_M
  • amino acids 173 to 267 (95 residues), 68.8 bits, E=7.8e-23
• PF00441: Acyl-CoA_dh_1
  • amino acids 279 to 425 (147 residues), 87.4 bits, E=2.4e-28
• PF08028: Acyl-CoA_dh_2
  • amino acids 293 to 413 (121 residues), 30.6 bits, E=7.5e-11

Best Hits

Swiss-Prot: 61% identical to GCDH_BOVIN: Glutaryl-CoA dehydrogenase, mitochondrial (GCDH) from Bos taurus

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 68% identity to cci:CC1G_09349)

MetaCyc: 58% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• glutaryl-CoA degradation (3/5 steps found)
• L-tryptophan degradation III (eukaryotic) (6/15 steps found)
• crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
• benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
• toluene degradation VI (anaerobic) (3/18 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7

Protein Sequence (432 amino acids)

>mRNA_3621 K00252 GCDH, gcdH glutaryl-CoA dehydrogenase (Rhodosporidium toruloides IFO0880)
MSLRLPLRQLAAKRVPPQALAARFASSEATAPAELAKTSSFAPYQWEDPLKVESTMLSEE
EVSIMEMARSYCQEKLAPRVTEAYRTENFDRSILSEMGELGLLGPTIDGYGCAGVSSVAY
GLVAREVERIDSGYRSAMSVQSSLVMHPINAFGSKQLKEKYLPRLAKGELVGCFGLTEPD
HGSDPAGMTTEAREAPGGGGFLISGAKTWISNAPIADVFVVWAKCQWDGKIRGFVLDKGM
KGLSAPAIKNKTALRASITGSIFMDEVSVPAEQMLDVQGLKGPFSCLNNARFGISFGAVG
ALEEAIRITREYALERKQFKKPLAGFQLVQQKLANAHMEAAIGLVSCVQLGRLKDSGNWS
PEMVSIMKRNNCQKALDHSRILMEVFGGNAASDEYPIARIAYNLHTVSTYEGTRDIHGLI
LGKAITGIAAFE