Protein Info for mRNA_3674 in Rhodosporidium toruloides IFO0880
Name: 12042
Annotation: K00128 ALDH aldehyde dehydrogenase (NAD+)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to ALDH_AGABI: Aldehyde dehydrogenase (aldA) from Agaricus bisporus
KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 64% identity to uma:UM02508.1)MetaCyc: 55% identical to mitochondrial aldehyde dehydrogenase subunit (Homo sapiens)
Phenylacetaldehyde dehydrogenase. [EC: 1.2.1.39]; Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.39, 1.2.1.3]; 1.2.1.3 [EC: 1.2.1.39, 1.2.1.3]; 1.2.1.3 [EC: 1.2.1.39, 1.2.1.3]; 1.2.1.3 [EC: 1.2.1.39, 1.2.1.3]; 1.2.1.3 [EC: 1.2.1.39, 1.2.1.3]
Predicted SEED Role
"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)
MetaCyc Pathways
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- phenylethylamine degradation I (2/2 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (3/4 steps found)
- phytol degradation (3/4 steps found)
- L-phenylalanine degradation II (anaerobic) (2/3 steps found)
- ethanol degradation III (2/3 steps found)
- hypotaurine degradation (2/3 steps found)
- putrescine degradation IV (2/3 steps found)
- ethylene glycol degradation (1/2 steps found)
- phenylethanol degradation (1/2 steps found)
- phenylethylamine degradation II (1/2 steps found)
- putrescine degradation I (1/2 steps found)
- putrescine degradation V (1/2 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- histamine degradation (1/3 steps found)
- styrene degradation (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- mitochondrial NADPH production (yeast) (2/5 steps found)
- octane oxidation (2/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (4/8 steps found)
- superpathway of ornithine degradation (4/8 steps found)
- D-arabinose degradation I (1/4 steps found)
- putrescine degradation III (1/4 steps found)
- serotonin degradation (3/7 steps found)
- superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
- Entner-Doudoroff pathway II (non-phosphorylative) (4/9 steps found)
- dopamine degradation (1/5 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
- superpathway of phenylethylamine degradation (5/11 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- limonene degradation IV (anaerobic) (2/7 steps found)
- superpathway of glycol metabolism and degradation (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (3/9 steps found)
- aromatic biogenic amine degradation (bacteria) (2/8 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (6/16 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (2/27 steps found)
- superpathway of pentose and pentitol degradation (6/42 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine degradation
- Phenylalanine metabolism
- Propanoate metabolism
- Pyruvate metabolism
- Styrene degradation
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.3
Use Curated BLAST to search for 1.2.1.3 or 1.2.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (503 amino acids)
>mRNA_3674 K00128 ALDH aldehyde dehydrogenase (NAD+) (Rhodosporidium toruloides IFO0880) MSNNLTASLTFPEGHSLKSLDFPVGLFINNEYSPASGGETIEVRAPAFDKVIAHVPRGTA EDVDRAVEAAQKAYDTVWGERCPGHKRGKLLMQLADLFEQHVEQLASIEALDNGKAYNIA KAFDVSEAAACLRYYGGWADKEHGKVIEVDNSKMAITKHEPIGVIGQIIPWNFPLLMFAW KLGPALACGNCIVIKVAETTPLSAFYATQLIAKVFPPGVVNVVTGYGNEVGAAISGHMKI LKVAFTGSTLVGRTIMQAAAKSNLKPVTLELGGKSPNIIFDDADMEQAVSWSAFGLFFNA GQCCCAGSRIFVQESIYDEFLEKLTAKVKSMKVGQPFAADSFVGPATSKLQFDRITAHIQ SGKDEGAKVHVGGNRHGDEGYFIEPTIFTDVTPNMRIAQEEIFGPVLVVQKFKDESDVVA KANDTMYGLAAAIFSRDISRAMRIANSVHAGTVWLNCYNQLNSQVPFGGFKQSGIGRELG SYALHNYTAVKAIHINLSQPNPL