Protein Info for mRNA_3923 in Rhodosporidium toruloides IFO0880

Name: 12291
Annotation: K01465 URA4, pyrC dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00856: dihydroorotase, homodimeric type
  • amino acids 5 to 371 (367 residues), 311.3 bits, E=3.6e-97
• PF01979: Amidohydro_1
  • amino acids 7 to 253 (247 residues), 22.9 bits, E=2.5e-09

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (15/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis I (5/6 steps found)
• UMP biosynthesis III (5/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (7/9 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (373 amino acids)

>mRNA_3923 K01465 URA4, pyrC dihydroorotase (Rhodosporidium toruloides IFO0880)
MSASITIPSPFDAHVHLRQGNMMKLVTPHVEQGGIKMAFVMPNLIPPLTVPEHTFAYVKE
LQAVAPNLHILPSLYLTNQLTPEHIRQAKAGGIIGVKSYPRGVTTNSEGGVGMEGYAVYD
EVFAEMEKQDMVLNLHGEVPSDVDGDGTCVLNAEERFLPHLREINRKFPKLRIVLEHCTT
AAAVECVKSLPSNVVATITPHHLALTIDGACSTSLGFCKPLAKFPSDRKALRAVVREGNP
KFFLGSDSAPHPSSSKLPALQVAQVKGADGSTEEEITLPSPCAAGIYTSSNLIPLTAEIF
ERSDIPLERMQGFCSKFGRDFYRFPAKEGEEVTIKRVEGKKVEKAFKYQTDKGEDEYIIP
FMAGDKIGWEIAA