Protein Info for mRNA_4187 in Rhodosporidium toruloides IFO0880

Name: 12555
Annotation: K01897 ACSL, fadD long-chain acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 123 to 583 (461 residues), 286.4 bits, E=1.6e-89

Predicted SEED Role

"Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)" in subsystem Biotin biosynthesis or n-Phenylalkanoic acid degradation (EC 6.2.1.3)

MetaCyc Pathways

• oleate β-oxidation (26/35 steps found)
• fatty acid salvage (5/6 steps found)
• γ-linolenate biosynthesis II (animals) (2/2 steps found)
• long-chain fatty acid activation (1/1 steps found)
• phytol degradation (3/4 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (22/31 steps found)
• stearate biosynthesis II (bacteria and plants) (4/6 steps found)
• linoleate biosynthesis II (animals) (1/2 steps found)
• long chain fatty acid ester synthesis (engineered) (2/4 steps found)
• alkane biosynthesis II (1/3 steps found)
• oleate biosynthesis I (plants) (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• stearate biosynthesis IV (3/6 steps found)
• octane oxidation (2/5 steps found)
• phosphatidylcholine acyl editing (1/4 steps found)
• wax esters biosynthesis II (1/4 steps found)
• 6-gingerol analog biosynthesis (engineered) (2/6 steps found)
• superpathway of fatty acid biosynthesis II (plant) (28/43 steps found)
• arachidonate biosynthesis III (6-desaturase, mammals) (2/7 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• icosapentaenoate biosynthesis II (6-desaturase, mammals) (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• stearate biosynthesis I (animals) (1/6 steps found)
• 2-deoxy-D-ribose degradation II (2/8 steps found)
• superpathway of fatty acids biosynthesis (E. coli) (34/53 steps found)
• capsaicin biosynthesis (1/7 steps found)
• icosapentaenoate biosynthesis III (8-desaturase, mammals) (1/7 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (6/16 steps found)
• palmitate biosynthesis III (14/29 steps found)
• sporopollenin precursors biosynthesis (4/18 steps found)
• cutin biosynthesis (1/16 steps found)
• suberin monomers biosynthesis (3/20 steps found)

KEGG Metabolic Maps

• Fatty acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.3

Use Curated BLAST to search for 6.2.1.3

Protein Sequence (730 amino acids)

>mRNA_4187 K01897 ACSL, fadD long-chain acyl-CoA synthetase (Rhodosporidium toruloides IFO0880)
MAAAATNPFPVELPQDHDVKRPQAVVRPRSFSSSSCPTSPRGSHRTLTTAWNARIQPLPN
SQKQGSTAVYVNAQFPEWVNRTFPKDVYQSFNLGLSIRAQNDCLGKREWDPALNDWARQL
TYESYESVDGHRTRVGSGLQVLRRELFPDENDVQWKVGIWSLNRPEWQYVNQACAAYSLT
IVSLYDIFGPEAVEYIVNHAETRVVFANPYHIPDLLKLGKRIPSVKAIVSLDSWASIAAK
GTRPGIQPAQAMKTWGESLGIRVLDLEELEQLGQANLAPHRPPTPDMIANICYTSGTTGN
PKGAILLQSNIAAVTASSEHGHAIRENSVVMSYLPLSHVYEYFVENIALATGAAIAYSCG
DNLRLLEDFQIAKPTFVCSVPRVLNRVYQGIKTQTIDAPGLKGALARKAFADKIHNLRTT
GQATHAIWDRILFNKVKQLMGGRVENLSTGSAPINPDVLDFLRVSFCCEVTEGYGQTETS
GCTNRCYNSDIWSAGAVGPPLAGVQMKLVDVPEMGYLSTDQPYPRGEICMKGANIIPGYY
KDPEKTRELIDEDGWLHSGDVGSIDQLGRLRIIDRVKNLVKLSQGEYVAVEKIENVYLLC
PLVAQMYVHGDGLRDHLVAIVNVDPIQFAPIASKALGKHLEPTDLAGLAEAAKDDKVVLA
VAQTLAKYARDARLLGFERIEDSLHLRVEPFPADCLTPTFKSKRNVIAKTYAKELAELYT
KAEGKARAKL