Protein Info for mRNA_4312 in Rhodosporidium toruloides IFO0880

Name: 12680
Annotation: K14802 DRS2, ATP8A phospholipid-transporting ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1172 transmembrane" amino acids 94 to 110 (17 residues), see Phobius details amino acids 117 to 134 (18 residues), see Phobius details amino acids 322 to 344 (23 residues), see Phobius details amino acids 376 to 397 (22 residues), see Phobius details amino acids 880 to 900 (21 residues), see Phobius details amino acids 917 to 941 (25 residues), see Phobius details amino acids 963 to 985 (23 residues), see Phobius details amino acids 1000 to 1020 (21 residues), see Phobius details amino acids 1028 to 1051 (24 residues), see Phobius details amino acids 1068 to 1087 (20 residues), see Phobius details PF16209: PhoLip_ATPase_N" amino acids 56 to 122 (67 residues), 91.4 bits, see alignment 5.9e-30 TIGR01652: phospholipid-translocating P-type ATPase, flippase" amino acids 70 to 1108 (1039 residues), 1329.2 bits, see alignment E=0 PF00122: E1-E2_ATPase" amino acids 150 to 341 (192 residues), 29 bits, see alignment E=1.8e-10 TIGR01494: HAD ATPase, P-type, family IC" amino acids 368 to 460 (93 residues), 64.2 bits, see alignment E=8e-22 amino acids 790 to 904 (115 residues), 104.6 bits, see alignment E=4.6e-34 PF00702: Hydrolase" amino acids 436 to 713 (278 residues), 29.7 bits, see alignment E=2e-10 PF13246: Cation_ATPase" amino acids 509 to 601 (93 residues), 43.2 bits, see alignment E=8.4e-15 PF16212: PhoLip_ATPase_C" amino acids 849 to 1100 (252 residues), 254.3 bits, see alignment E=3.9e-79

Best Hits

KEGG orthology group: K14802, phospholipid-transporting ATPase [EC: 3.6.3.1] (inferred from 66% identity to cne:CNA03720)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.1

Use Curated BLAST to search for 3.6.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1172 amino acids)

>mRNA_4312 K14802 DRS2, ATP8A phospholipid-transporting ATPase (Rhodosporidium toruloides IFO0880)
MLDDDDELVQAKARIAARQAKSQRALEARGTLEGLWKDVKRVVKGGPRVYQGERVVHLNN
ETMNKAEKWPGNSVSTSKYNIVTFLPKFLAEQFSKYANIFFLFTACIQQIPNVSPTNRYT
TILPLGIVLIVAALKEIKEDIKRHQSDADLNSRKASILQGSTFVDKPWRSIKVGDIVRLE
ANDAFPADLVLLSSSEPEGLCYIETSNLDGETNLKIKQAHQSTASLHSPHALAQLAGHLR
SEQPNNSLYTFEATLSMGQPGHAATSSETPLGPDQLLLRGAQLRNTSWLYGLVVFTGHET
KLMRNATAAPIKRTAMERMVNVQILFLLAILLALSLACAIGSTIRTHVYGDDMWYLLLDD
GGESSPVSASKFVKDVLTFILTLNNLIPISLIVTMEVVKFQQAAFINNDLDMYYAPTDTP
ALCRTSSLVEELGQIEYIFSDKTGTLTCNQMEFRQCSIGGIPYADIVEESKRGEVFSFDQ
LRDNLANGHETSKVIEEFLTLLSTCHTVIPERKDEKITYQASSPDEAALVQGADVLGYTF
TTRKPQSVFVNIASRGSREFEILNILEFNSTRKRMSAIVRTPEGKIKLYCKGADTVIYER
LASEGQVFSEVTSNHLEEYATEGLRTLCIAMRDIPEDEYKKWAVIHQKAAATISGRTEAL
DKAAEIIERDLFLLGATAIEDKLQEGVPDTIYTLQQAGIKVWVLTGDRQETAINIGLSCR
LISESMSLVIVNEENALDTKDFLVKRLEAVKNSRNAGDFEELALVIDGKSLSFALEKELS
KTFLELAVMCKAVVCCRVSPLQKALVVKLVKKNLKAILLAIGDGANDVSMIQAAHVGVGI
SGVEGLQAARSADVAISQFRYLKKLLLVHGTWSYVRLSKLILYSFYKNIALYMTGFWFAF
QNSFSGQVLEEGWTLTFYNVVFTVLPPIVLGVFDQFVGARMLDRYPELYKLGQNNKFFSV
RIFWQWIINALLHSFVIYVCTVAIFNEGLILVQGWISGQWVWGTTLYLTALVTVLGKAAI
ISDIWTKYTLLAIPGSFAFTMVFLPLYAWIAPMLGFSLEYTDIVSRLWTSLIFWLTIIGI
SVLLLVRDFAWKSYKRLFMPEPYHIVQEIQKYNLPDYRPRMEQFQKAIKKVRAVQRLRRN
RGFAFSQTEEGQEHLIRAYDTSVTPGGKRLET