Protein Info for mRNA_4576 in Rhodosporidium toruloides IFO0880

Name: 12944
Annotation: K00787 FDPS farnesyl diphosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00348: polyprenyl_synt
  • amino acids 36 to 299 (264 residues), 330.3 bits, E=3.3e-103

Best Hits

Swiss-Prot: 64% identical to FPPS_KLULA: Farnesyl pyrophosphate synthase (FPS1) from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)

KEGG orthology group: K00787, farnesyl diphosphate synthase [EC: 2.5.1.1 2.5.1.10] (inferred from 71% identity to cnb:CNBE4510)

MetaCyc: 65% identical to Erg20 (Saccharomyces cerevisiae)
Geranyltranstransferase. [EC: 2.5.1.10]; Dimethylallyltranstransferase. [EC: 2.5.1.10, 2.5.1.1]

Predicted SEED Role

"Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) / Dimethylallyltransferase (EC 2.5.1.1) / (2E,6E)-farnesyl diphosphate synthase (EC 2.5.1.10)" in subsystem Archaeal lipids or Isoprenoid Biosynthesis (EC 2.5.1.1, EC 2.5.1.10)

MetaCyc Pathways

• superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) (10/10 steps found)
• trans, trans-farnesyl diphosphate biosynthesis (2/2 steps found)
• geranyl diphosphate biosynthesis (1/1 steps found)
• all-trans-farnesol biosynthesis (3/4 steps found)
• (3R)-linalool biosynthesis (1/2 steps found)
• (3S)-linalool biosynthesis (1/2 steps found)
• linalool biosynthesis I (1/2 steps found)
• polyisoprenoid biosynthesis (E. coli) (3/5 steps found)
• methyl phomopsenoate biosynthesis (2/4 steps found)
• superpathway of linalool biosynthesis (1/3 steps found)
• bisabolene biosynthesis (engineered) (3/6 steps found)
• mono-trans, poly-cis decaprenyl phosphate biosynthesis (2/5 steps found)
• ipsdienol biosynthesis (1/4 steps found)
• superpathway of ergosterol biosynthesis I (16/26 steps found)
• stellatic acid biosynthesis (3/8 steps found)
• superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (5/12 steps found)
• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (4/12 steps found)
• taxadiene biosynthesis (engineered) (4/13 steps found)
• viridicatumtoxin biosynthesis (1/9 steps found)
• superpathway of cholesterol biosynthesis (14/38 steps found)
• superpathway of ergosterol biosynthesis II (5/26 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (10/33 steps found)
• superpathway of chorismate metabolism (28/59 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (26/57 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.5.1.1, 2.5.1.10

Use Curated BLAST to search for 2.5.1.1 or 2.5.1.10

Protein Sequence (350 amino acids)

>mRNA_4576 K00787 FDPS farnesyl diphosphate synthase (Rhodosporidium toruloides IFO0880)
MSSAEKRDQFLAVWPALADELVQYMEGEKMPKEAVDWFRRSLDYNTPGGKLNRGISVVDT
VQILKGSELSADEYKRAAILGWCIELLQAYFLVADDMMDQSITRRGQPCWYRVENVGNIA
INDAFMLEAAIYYLLKKHFRQKKYYVDLLEIFHEVTFQTELGQLIDLITAPEDVVDLSKF
SLDKHHLIVVYKTAYYSFYLPVALALHMAGVSSPSAYQKALDILIPMGEYFQVQDDYLDC
YGTPEQIGKIGTDILDNKCSWLVNKALQKASPEQRKVLDDNYGVKSSESEARVKAVYKEL
ELAREFEQYEADSYKRINALIEEIPAEGSQDGLKREVFQSFLAKVYKRQK