Protein Info for mRNA_4692 in Rhodosporidium toruloides IFO0880

Name: 13060
Annotation: K00559 E2.1.1.41, SMT1, ERG6 sterol 24-C-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 PF02353: CMAS" amino acids 49 to 265 (217 residues), 52.4 bits, see alignment E=2.6e-17 PF01135: PCMT" amino acids 95 to 188 (94 residues), 24 bits, see alignment E=1.5e-08 PF01209: Ubie_methyltran" amino acids 95 to 213 (119 residues), 35 bits, see alignment E=5.2e-12 PF13489: Methyltransf_23" amino acids 102 to 216 (115 residues), 45.3 bits, see alignment E=4.6e-15 PF13847: Methyltransf_31" amino acids 102 to 213 (112 residues), 68.2 bits, see alignment E=3.7e-22 PF09445: Methyltransf_15" amino acids 107 to 179 (73 residues), 21.7 bits, see alignment E=6.6e-08 PF13649: Methyltransf_25" amino acids 108 to 205 (98 residues), 59.7 bits, see alignment E=1.9e-19 PF08241: Methyltransf_11" amino acids 109 to 207 (99 residues), 62.7 bits, see alignment E=2.2e-20 PF08242: Methyltransf_12" amino acids 109 to 207 (99 residues), 45.5 bits, see alignment E=5.2e-15 PF08498: Sterol_MT_C" amino acids 292 to 355 (64 residues), 98.9 bits, see alignment E=8.3e-32

Best Hits

Swiss-Prot: 54% identical to ERG6_ASPFU: Sterol 24-C-methyltransferase (erg6) from Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)

KEGG orthology group: K00559, sterol 24-C-methyltransferase [EC: 2.1.1.41] (inferred from 67% identity to cnb:CNBB2600)

MetaCyc: 54% identical to sterol 24-C-methyltransferase subunit (Saccharomyces cerevisiae)
Sterol 24-C-methyltransferase. [EC: 2.1.1.41]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (358 amino acids)

>mRNA_4692 K00559 E2.1.1.41, SMT1, ERG6 sterol 24-C-methyltransferase (Rhodosporidium toruloides IFO0880)
MVSDSSSRALTEQPKGQDVRNRAGIASYTAHWDAQSSLDTAAHTSRRKDHYTDVVNGYYD
GATELYEYGWGESFHFCRYYEGEPFYQAIARHEHYLAHMAGIKKGDKVLDVGCGVGGPAR
EIARFTDCNIIGVNNNEFQVLRARKKTAKAGLSDQVSFVKGDFMALVEQFGENSFDAVYA
IEATCHAPSWEGVYGQIFKVLKPGGVFGVYEWCMSDTFDQSNPRHKEIQHGIELGNGIPE
MRPIALARDALKTVGFEIEHEEDLAQRDDPVEWWFSISGDLSKCQSVWDFPTLFRMTKVG
RNITGYGVWALEKLGLVPKGTWDVQEALKVAADSLVAGAKENLFTPMMLFVARKPHSQ