Protein Info for mRNA_4871 in Rhodosporidium toruloides IFO0880

Name: 13239
Annotation: K03777 dld D-lactate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01565: FAD_binding_4
  • amino acids 144 to 241 (98 residues), 59.4 bits, E=3.5e-20
• PF02913: FAD-oxidase_C
  • amino acids 284 to 526 (243 residues), 185.2 bits, E=1.8e-58

Predicted SEED Role

"D-Lactate dehydrogenase, cytochrome c-dependent (EC 1.1.2.4)" in subsystem Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 1.1.2.4)

MetaCyc Pathways

• methylglyoxal degradation VIII (3/3 steps found)
• methylglyoxal degradation VI (1/4 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.2.4

Use Curated BLAST to search for 1.1.2.4

Protein Sequence (537 amino acids)

>mRNA_4871 K03777 dld D-lactate dehydrogenase (Rhodosporidium toruloides IFO0880)
MAARATAQRRLASVSSQLAPAVAPPAPDWNGALEALQSVFPPEQFSLDLPTREKYGTGWG
SLLPPAPPAAILHAVRTEDVVEVVRIATRFGIVLIPTGGRTALEGQFQASCCNPPAGERW
TGVGNDEEDERPRDGKKRETARTERPTIQVSLSRMNKVLAVHEQDFQAVVQPGIGWQGLN
EFLAKKGIKLFFPVDPAPGSEFGGMAGVAGSGTNAVGYGTLRAEWIQSMEVVLMNGDVIR
TRGTNRARKSSTGWDTGRLFLGSEGTLGIITELTVRLAPVLPLKVALTSFPTISSAVSSV
VSILTSGLSPTSLELLDGTSIRGLNLARILPEELREEPTVLMRFSNASEEVNRQDLEKVK
GIVRENGGRELRVARDERENEELWKARKSQYWSQQLLVGEGCRTLITDICVPISRLAEFI
SRSDSYVSTSGLYAPIVAHIGDGNVHRAILWKGREGETKPPRAVEELAGKLVRLAQELEG
TCAGEHGIGLTKRKYLRAELGEGTLALMRTVKRALDPLNLLNPDKVLFPKGEEEWDA