Protein Info for mRNA_5249 in Rhodosporidium toruloides IFO0880

Name: 13617
Annotation: K01535 PMA1, PMA2 H+-transporting ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1001 transmembrane" amino acids 133 to 158 (26 residues), see Phobius details amino acids 170 to 187 (18 residues), see Phobius details amino acids 319 to 340 (22 residues), see Phobius details amino acids 353 to 376 (24 residues), see Phobius details amino acids 723 to 745 (23 residues), see Phobius details amino acids 751 to 770 (20 residues), see Phobius details amino acids 791 to 814 (24 residues), see Phobius details amino acids 834 to 851 (18 residues), see Phobius details amino acids 863 to 883 (21 residues), see Phobius details amino acids 898 to 920 (23 residues), see Phobius details PF00690: Cation_ATPase_N" amino acids 91 to 155 (65 residues), 49.7 bits, see alignment 4.9e-17 TIGR01647: plasma-membrane proton-efflux P-type ATPase" amino acids 107 to 883 (777 residues), 1104 bits, see alignment E=0 TIGR01494: HAD ATPase, P-type, family IC" amino acids 174 to 440 (267 residues), 137.4 bits, see alignment E=4.9e-44 amino acids 639 to 751 (113 residues), 92.9 bits, see alignment E=1.6e-30 PF00122: E1-E2_ATPase" amino acids 202 to 382 (181 residues), 156.3 bits, see alignment E=1.2e-49 PF00702: Hydrolase" amino acids 400 to 678 (279 residues), 61.4 bits, see alignment E=3.3e-20

Best Hits

Swiss-Prot: 56% identical to PMA3_ARATH: ATPase 3, plasma membrane-type (AHA3) from Arabidopsis thaliana

KEGG orthology group: K01535, H+-transporting ATPase [EC: 3.6.3.6] (inferred from 75% identity to scm:SCHCODRAFT_86036)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5, 3.6.3.6

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5 or 3.6.3.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1001 amino acids)

>mRNA_5249 K01535 PMA1, PMA2 H+-transporting ATPase (Rhodosporidium toruloides IFO0880)
MSAPLHNNEHGAQPEVVEEKHAAPPAAAPAAAAPAPQQEGTAPAAPTEKKAGRFDKTFEE
EREVKHALVDMSTIELKAEDLYDKDKVDLEQVEMEDVWTLLQCKEDGLTNAEAERRRGIF
GPNKLEHKETSVLLQFLSFMWNPLSWVMEGAALVAIALSNGEGRAPDWQDFVGIVLLLFI
NSTIGFYEERSAGNAVKALMESLAPKAKCKRDGTWIEIESSDLVPGDVISFKIGDIVPAD
CRLYDAINVSIDQAGLTGESLPQGKKVGDQCFSSSICKQGEAEGVVIATGANTFFGRAAS
LVGADDDSTGHLQQILAQIGLFCLVSIGIFILLEILILYPRFHYSYRRGLDNILVLLIGG
IPIAMPTVLSVTLAVGAQQLAKYKAIVTRITAIEELAGVTILCSDKTGTLTTNKLTIDKS
TLKTYSSFNADEVILYAAYASRTENMDAIDTCVTGALPSVADARAGIKLLDFKPFNPVDK
RTEITYTVDATGEMKRATKGMTGIIIELCSRNKTAEVEDQLEKDVEEYAARGLRALAVAV
EDVPSGNKDEPGNGFELIGLLAIFDPPRDDTKQTIDEAIALGVRVKMVTGDQLAIAKETG
RRLGLGDHMYPAKVLQTGGFPEGGKHMNLDEMILDADGFAGVFPEHKYEIVKRLQGLGHL
CAMTGDGANDAPALSRANVGIAVEGATDAARGAADIVLTEPGLSTIVHAIRQSRVIFQRM
RNYSIYACAVTIRIVVGFAVMAFAFQFDFPPFMVLIIALLNDGTIMTLSLDRVLPSTTPD
SWDLGEIFTYAFAYGLYLAAGTIAFYCVIIYTTFFTRKFGVNDITDHNDPDVHMIIYLQV
AQISQALIFVTRSHSFFFMERPSVALFLAFCLAQLISSIIAAYGDWGFTNVRGVSGGWIG
ITWIWNIIWFFPLDFVKFGVRAGVRAWNRRRGKTPQAIKPVEGVPMTRTQSRHESLYSNR
TSFLRRAQRSVGLGRKVHVSNADLQRFGSHQASASGAALRA